{"id":"W4362594105","doi":"10.1158/1538-7445.am2023-3938","title":"Abstract 3938: <i>In vivo</i> genome-wide CRISPR screen in pancreatic ductal adenocarcinoma defines HSPE1 as a potential oncogene by acting through G2/M cell cycle arrest","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Carcinogenesis; Cancer research; CRISPR; Cell cycle checkpoint; Cell cycle; Pancreatic cancer; Small hairpin RNA; Biology; Oncogene; Cancer; Gene knockdown; KRAS; In vivo; Cell culture; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001648532,0.0004850097,0.0004889137,0.0003310242,0.0002810334,0.0003586556,0.0003018884,0.0004372542,0.005389368],"category_scores_gemma":[0.0001220445,0.0001852346,0.0004099196,0.0003326471,0.0002319541,0.0001276355,0.0002848227,0.0007580579,0.001620402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003453064,"about_ca_system_score_gemma":0.0002498873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001264215,"about_ca_topic_score_gemma":0.001623258,"domain_scores_codex":[0.9997482,0.00002874415,0.00002753566,0.00007628083,0.00007800448,0.00004118906],"domain_scores_gemma":[0.999859,0.00002817427,0.0000367911,0.00002586075,0.00001710441,0.00003298713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004454135,0.00001776495,0.0001433015,0.00003416739,0.000005103257,0.00005628531,0.000005578243,0.00006403393,0.998524,0.00005630275,0.0002121901,0.0008367421],"study_design_scores_gemma":[0.00001191284,0.0001748745,0.003485282,0.000006346816,0.00002289202,0.0003500422,0.00001561758,0.0007534102,0.9894556,0.00003392623,0.005684049,0.000006003637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9244428,0.002187615,0.03005152,0.0008215645,0.0002329498,0.0003060801,0.02670305,0.002756092,0.01249833],"genre_scores_gemma":[0.9495535,0.001250574,0.01163957,0.0004121196,0.00002360008,0.0002331464,0.01703139,0.0005310139,0.01932526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005389368,"threshold_uncertainty_score":0.01802921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0240889135923905,"score_gpt":0.3631005337458455,"score_spread":0.339011620153455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}