{"id":"W4362594156","doi":"10.1158/1538-7445.am2023-5760","title":"Abstract 5760: Molecular, immune, and microbial profiles of early-onset, intermediate-onset, and later-onset CRCs","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"KRAS; Microsatellite instability; Colorectal cancer; Age of onset; Medicine; Internal medicine; Cancer; Oncology; Gastroenterology; Biology; Genetics; Disease; Gene; Microsatellite; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002328719,0.0001421711,0.0001467318,0.001259702,0.0003244275,0.0003649919,0.0002300546,0.0002210865,0.001982657],"category_scores_gemma":[0.0006801657,0.0001140299,0.0001362586,0.0008108288,0.0002761166,0.0001567214,0.0002152989,0.0001427552,0.0002491793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007094202,"about_ca_system_score_gemma":0.0003425056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03656727,"about_ca_topic_score_gemma":0.04920411,"domain_scores_codex":[0.9997894,0.00001740796,0.00002096439,0.00005778373,0.00005562145,0.00005875653],"domain_scores_gemma":[0.9995381,0.00006059064,0.000201689,0.00002869123,0.00008074373,0.00009020312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006439402,0.000005042018,0.9971129,0.00000616719,0.000004819733,0.00008612584,0.00005047226,0.000008285332,0.001954633,0.000005261863,0.00004544585,0.0006565081],"study_design_scores_gemma":[0.000001154633,0.00001439097,0.9993355,0.000001499429,0.000004205609,0.0002019791,0.00007232346,0.00002870046,0.0002586261,0.000003856352,0.00007711461,6.414411e-7],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991703,0.0001022335,0.00006089617,0.00001160966,9.82008e-7,0.000004532993,0.0003563149,0.000003072431,0.0002900751],"genre_scores_gemma":[0.9993717,0.00003372263,0.00008214539,0.000008013845,0.00000182206,0.000003559916,0.0003241137,0.000001213405,0.0001737763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03656727,"threshold_uncertainty_score":0.07270885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04423971322434717,"score_gpt":0.3780475635882365,"score_spread":0.3338078503638893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}