{"id":"W4362594416","doi":"10.1158/1538-7445.am2023-4729","title":"Abstract 4729: LSD1 activates oncogenic super-enhancers in castration-resistant prostate cancer by forming nuclear condensates with BRD4","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"FOXA1; Androgen receptor; Cancer research; Coactivator; Prostate cancer; BRD4; Transcription factor; Demethylase; Enhancer; Enzalutamide; EZH2; Chromatin; Transactivation; Biology; Chemistry; Histone; Cancer; Bromodomain; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009396445,0.0002364361,0.0002423363,0.0002511245,0.0001517292,0.0002482687,0.0001217188,0.0001165076,0.001597577],"category_scores_gemma":[0.00005315202,0.0001077778,0.0002793166,0.0001732072,0.0001839122,0.00007379387,0.0001527381,0.0004198706,0.0004130818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004067064,"about_ca_system_score_gemma":0.0003226287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001757769,"about_ca_topic_score_gemma":0.002712988,"domain_scores_codex":[0.9998914,0.000008602778,0.000006200125,0.00002424745,0.00004374166,0.00002583974],"domain_scores_gemma":[0.9999477,0.000004998202,0.00001603232,0.000005684576,0.000005101645,0.00002053426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000745826,0.00001464378,0.0002493139,0.00002312322,0.000004299802,0.00002230128,0.000006262694,0.00006523146,0.9988523,0.00003682899,0.00005750971,0.0005937996],"study_design_scores_gemma":[0.00001979421,0.0003524948,0.01172317,0.000004646855,0.0000199502,0.0001923932,0.00003572457,0.001217691,0.9831417,0.00003132148,0.003255505,0.000005613523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933178,0.001498361,0.00174617,0.0001048023,0.00003003637,0.0000302198,0.002067142,0.0001905434,0.00101474],"genre_scores_gemma":[0.9928977,0.0004723686,0.001059621,0.00006277955,0.000005249563,0.00002239163,0.00228731,0.00002750016,0.003165068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001757769,"threshold_uncertainty_score":0.00534445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07513378526280544,"score_gpt":0.4147922004104936,"score_spread":0.3396584151476882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}