{"id":"W4362594427","doi":"10.1158/1538-7445.am2023-5882","title":"Abstract 5882: Prevention of antibiotic-induced dysbiosis in human volunteers by DAV132 and preservation of responsiveness to anti-PD-1 demonstrated by transplantation of human feces into tumor-bearing mice","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Dysbiosis; Ceftazidime; Antibiotics; Human microbiome; Piperacillin/tazobactam; Medicine; Piperacillin; Avibactam; Microbiome; Pharmacology; Gut flora; Microbiology; Immunology; Internal medicine; Biology; Bacteria; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001469724,0.000307881,0.0004360758,0.0001411668,0.0001551527,0.0002046331,0.0001025699,0.0002823717,0.003106904],"category_scores_gemma":[0.000188868,0.0001293671,0.0002043539,0.000109974,0.0002281368,0.0001418133,0.0001718163,0.0004006917,0.0004350771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001067747,"about_ca_system_score_gemma":0.0002191566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003143424,"about_ca_topic_score_gemma":0.0003701262,"domain_scores_codex":[0.9998616,0.00002633388,0.000008773095,0.00004811665,0.00002310671,0.00003200885],"domain_scores_gemma":[0.999902,0.00001061387,0.00002166481,0.00001188838,0.000009725633,0.00004398244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0190937,0.001252906,0.004019938,0.000114209,0.000027163,0.0001062792,0.00004960263,0.00009545531,0.9550897,0.00004011132,0.0004638755,0.01964709],"study_design_scores_gemma":[0.0025998,0.1809335,0.1309973,0.00006127994,0.0001800233,0.001876677,0.0003189853,0.001825912,0.6704489,0.0002100621,0.01050328,0.00004426986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979283,0.0006013965,0.0005651044,0.00008563689,0.00004245965,0.00005072091,0.000327523,0.00003619292,0.0003626826],"genre_scores_gemma":[0.9969417,0.0002942187,0.000695072,0.00007057229,0.00002352817,0.00007948538,0.0003979055,0.00001076175,0.001486592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003106904,"threshold_uncertainty_score":0.01039356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0529711391113715,"score_gpt":0.4109218020582572,"score_spread":0.3579506629468857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}