{"id":"W4362594938","doi":"10.1158/1538-7445.am2023-578","title":"Abstract 578: Novel bi-thiazole LOX inhibitors to overcome chemotherapy resistance in triple negative breast cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Microbial metabolism and enzyme function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University","funders":"","keywords":"Triple-negative breast cancer; Breast cancer; Cancer research; Chemotherapy; Medicine; Lysyl oxidase; Doxorubicin; Cancer; Breast cancer chemotherapy; Oncology; Internal medicine; Chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009850971,0.0003294742,0.0004147138,0.0002994644,0.0001269958,0.0002520944,0.0002684327,0.0002773217,0.002010204],"category_scores_gemma":[0.00007929789,0.0001099618,0.0002257596,0.0002573728,0.0001054432,0.0001401169,0.0001838032,0.0007084831,0.0006431211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002693086,"about_ca_system_score_gemma":0.0002098649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000894992,"about_ca_topic_score_gemma":0.002676857,"domain_scores_codex":[0.9999554,0.000005496162,0.000003935999,0.000009772324,0.000012589,0.00001276184],"domain_scores_gemma":[0.9999715,0.000002636919,0.000006251191,0.000002208415,0.000007650849,0.000009780416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008338836,0.0004117371,0.0007977398,0.0006360703,0.00006624276,0.0003413934,0.000068935,0.0009858394,0.9438173,0.000479106,0.003615453,0.04794627],"study_design_scores_gemma":[0.00191053,0.009665657,0.01798983,0.0002249807,0.0004265298,0.002731818,0.0001593856,0.01046224,0.8684682,0.0005494734,0.08730967,0.0001017079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9374419,0.03872674,0.007171073,0.00106626,0.0003396521,0.0004461915,0.002758569,0.000680781,0.01136897],"genre_scores_gemma":[0.9652092,0.01437014,0.004186388,0.0005957137,0.00004123648,0.0002169903,0.003336678,0.00004334709,0.01200037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002010204,"threshold_uncertainty_score":0.006724775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03700720814003581,"score_gpt":0.3536754526585529,"score_spread":0.3166682445185171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}