{"id":"W4362595178","doi":"10.1158/1538-7445.am2023-2610","title":"Abstract 2610: <i>GNAQ/GNA11</i> and <i>BAP1</i> mutant isogenic cell lines engineered by CRISPR/Cas9 gene editing to model ocular melanoma","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"GNAQ; Biology; CRISPR; Molecular biology; Genetics; Gene; Cancer research; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004483383,0.0005052403,0.0003757806,0.0005209019,0.0003296982,0.0004358414,0.0007099133,0.0008810775,0.004264173],"category_scores_gemma":[0.0002563034,0.0003556245,0.0005048765,0.0002939294,0.0004335329,0.000224512,0.0004685679,0.001698916,0.002406046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005096775,"about_ca_system_score_gemma":0.0003293593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001610895,"about_ca_topic_score_gemma":0.001901945,"domain_scores_codex":[0.9993456,0.00007475763,0.00008813172,0.0001720023,0.0002264493,0.00009301484],"domain_scores_gemma":[0.9996327,0.00007049812,0.00009157323,0.0000695707,0.00004729834,0.00008831659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008866078,0.00008538077,0.0001592458,0.00004762568,0.0000102324,0.000151119,0.00004724937,0.0002165755,0.9970589,0.0005704719,0.0003132671,0.00125136],"study_design_scores_gemma":[0.00004742102,0.0003584724,0.002068635,0.00001897041,0.00003279106,0.0007331202,0.00005595481,0.003483249,0.9746193,0.0001321086,0.01843064,0.00001937981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8897182,0.001234063,0.07714383,0.0006168179,0.0006114584,0.001254906,0.01237166,0.001747207,0.01530185],"genre_scores_gemma":[0.9089757,0.0008384188,0.04511004,0.0003049831,0.00003623961,0.001092657,0.009810871,0.0007536128,0.03307746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004264173,"threshold_uncertainty_score":0.01426506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02993475153702465,"score_gpt":0.3537900385713593,"score_spread":0.3238552870343347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}