{"id":"W4362595462","doi":"10.1158/1538-7445.am2023-3997","title":"Abstract 3997: Preclinical characterization of ARX517, a next-generation anti-PSMA antibody drug conjugate for the treatment of metastatic castration-resistant prostate cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Micropharma (Canada)","funders":"","keywords":"Prostate cancer; Cancer research; Cancer; Medicine; Antibody-drug conjugate; Cancer cell; Antibody; Prostate; Antigen; Internal medicine; Immunology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002246639,0.0003204348,0.000237283,0.0002361878,0.0001303902,0.0001846007,0.0002000377,0.0003010342,0.002023426],"category_scores_gemma":[0.0001521319,0.0001232567,0.000248568,0.0001480201,0.0001000528,0.0001486374,0.0000894269,0.000351611,0.0006714871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002120675,"about_ca_system_score_gemma":0.000363364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008404972,"about_ca_topic_score_gemma":0.0008507602,"domain_scores_codex":[0.9998968,0.00002330293,0.000005731809,0.00001432662,0.00003788034,0.00002199458],"domain_scores_gemma":[0.9999197,0.00001367683,0.00001275452,0.000007938501,0.00002484038,0.0000212359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003364869,0.0006183389,0.0002694466,0.00009533502,0.00002047631,0.00007960817,0.00002982441,0.001450996,0.989886,0.0001438875,0.0005262865,0.006543258],"study_design_scores_gemma":[0.0001149841,0.008957804,0.001839938,0.00001197019,0.000033782,0.0002054265,0.00001381224,0.003689668,0.9795043,0.00004080572,0.0055767,0.00001089837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886512,0.001771963,0.003789917,0.0001056365,0.0000494478,0.0004229269,0.001057069,0.0001072929,0.00404462],"genre_scores_gemma":[0.9877074,0.001144,0.003761299,0.00008033213,0.00001371414,0.0001861078,0.00186883,0.00003774348,0.005200671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002023426,"threshold_uncertainty_score":0.006769061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2840586282121687,"score_gpt":0.4957332882409141,"score_spread":0.2116746600287454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}