{"id":"W4362595587","doi":"10.1158/1538-7445.am2023-2633","title":"Abstract 2633: Zanidatamab zovodotin (ZW49) induces hallmarks of immunogenic cell death and is active in patient-derived xenograft models of gastric cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Calreticulin; Cancer research; Cancer; Immunogenic cell death; Antibody; Medicine; Flow cytometry; Cancer cell; Immunology; Biology; Internal medicine; Cell biology; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001427041,0.000273464,0.0003031606,0.0002046952,0.0001196384,0.0002118569,0.0001721569,0.0002552696,0.00245727],"category_scores_gemma":[0.00008329881,0.00009565222,0.0002344642,0.0001943686,0.0001168312,0.0001487941,0.0001173314,0.0006525021,0.0004174208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002982816,"about_ca_system_score_gemma":0.0002227893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008030969,"about_ca_topic_score_gemma":0.001186679,"domain_scores_codex":[0.9998912,0.00002108105,0.000009853268,0.00001505758,0.00003245044,0.00003041319],"domain_scores_gemma":[0.9999524,0.000009183147,0.00001175891,0.000006340412,0.000007222515,0.00001300447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009416137,0.0002531004,0.0004584818,0.00005039937,0.00001370498,0.00009050973,0.00001502914,0.0001735432,0.9943709,0.00008712267,0.0002998484,0.003245753],"study_design_scores_gemma":[0.0001991026,0.004412617,0.00972977,0.000005752511,0.00002918011,0.0006583023,0.00004032962,0.001339618,0.9798656,0.00003080682,0.00368473,0.000004061208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957897,0.0009253289,0.0007538117,0.00008742422,0.00003287516,0.00005390253,0.0009714552,0.00005249214,0.001332926],"genre_scores_gemma":[0.9939359,0.0006384453,0.0009485643,0.00003940699,0.000008361476,0.00004915001,0.002289793,0.00001165328,0.002078761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00245727,"threshold_uncertainty_score":0.008220375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1182232486176868,"score_gpt":0.4046570870025205,"score_spread":0.2864338383848337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}