{"id":"W4362595767","doi":"10.1158/1538-7445.am2023-4833","title":"Abstract 4833: Inhibiting the mitochondrial RNA degradosome complex SUV3 and PNPase increases dsRNA in the cytoplasm, triggers a viral mimicry response and kills AML cells and progenitors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Biology; Gene knockdown; Small hairpin RNA; RNA interference; Myeloid leukemia; Molecular biology; Cell biology; Cancer research; RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317913,0.0003670611,0.0004139008,0.0002894108,0.0001645326,0.0003913557,0.0002005625,0.0002551587,0.005166317],"category_scores_gemma":[0.0001454648,0.0001249854,0.0003361733,0.0002525147,0.0001379131,0.0001310978,0.0001897532,0.0007073436,0.001116114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000298117,"about_ca_system_score_gemma":0.0003192264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001236342,"about_ca_topic_score_gemma":0.001745751,"domain_scores_codex":[0.9997695,0.0000163608,0.00002458325,0.0000477592,0.00009663813,0.00004512829],"domain_scores_gemma":[0.9998964,0.00002080121,0.00002525805,0.00001126071,0.00001206542,0.00003416121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002685465,0.00005496034,0.0003610723,0.00006102882,0.00001356402,0.0000335691,0.000007683922,0.0001740688,0.9955451,0.00008719627,0.0006343753,0.002758703],"study_design_scores_gemma":[0.00003369011,0.0003195326,0.004946735,0.000006293009,0.0000250645,0.0001345117,0.000018634,0.001449315,0.9883453,0.00004377598,0.004673124,0.00000398387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726261,0.001713303,0.004137305,0.000343646,0.0001523129,0.0001069171,0.01518189,0.001168903,0.004569605],"genre_scores_gemma":[0.9698341,0.0007764885,0.003861237,0.0001788263,0.00001420976,0.0001293392,0.01687219,0.0001347266,0.008198983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005166317,"threshold_uncertainty_score":0.01728308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05977300108846799,"score_gpt":0.3537148730375583,"score_spread":0.2939418719490903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}