{"id":"W4362595928","doi":"10.1158/1538-7445.am2023-6127","title":"Abstract 6127: MDM2 inhibition in combination with MEK inhibition in pre-clinical models of lung adenocarcinomas with <i>MDM2</i> amplification","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"MAPK/ERK pathway; Trametinib; Cancer research; MEK inhibitor; Kinase; Growth inhibition; Phosphorylation; Mdm2; Medicine; Targeted therapy; Cell culture; Cell growth; Cancer; Chemistry; Internal medicine; Biology; Cell biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002992675,0.000460182,0.0005528537,0.000419133,0.0002389273,0.0003941256,0.0004489917,0.000325923,0.002827653],"category_scores_gemma":[0.0001661451,0.0001989798,0.000359691,0.0002502006,0.0002924884,0.000337716,0.0002067853,0.001396707,0.000782603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005208409,"about_ca_system_score_gemma":0.0005291833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001381968,"about_ca_topic_score_gemma":0.00328901,"domain_scores_codex":[0.9997517,0.00006513044,0.00001951077,0.00003652041,0.00005671927,0.00007035908],"domain_scores_gemma":[0.9998373,0.00002944687,0.00002260527,0.00002390021,0.00001549094,0.00007116556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006243485,0.002885518,0.001732466,0.0001501154,0.00004467727,0.0002697081,0.00004643677,0.0008806988,0.974956,0.0002245626,0.001247942,0.01131842],"study_design_scores_gemma":[0.0003930132,0.02319381,0.009801056,0.00001456344,0.00005611379,0.0007118654,0.00007525946,0.003060333,0.9586057,0.0000767794,0.003996133,0.00001532798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947512,0.001010854,0.0006171959,0.0002256988,0.00008773122,0.00009225879,0.0008050228,0.0001080066,0.002302012],"genre_scores_gemma":[0.9950917,0.0005482655,0.0009690492,0.0000431383,0.00001697832,0.00008162388,0.0008881283,0.00001514118,0.002346009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002827653,"threshold_uncertainty_score":0.009459436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1155378624649433,"score_gpt":0.4134202785240412,"score_spread":0.2978824160590978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}