{"id":"W4362596003","doi":"10.1158/1538-7445.am2023-4774","title":"Abstract 4774: Adaptation to chronic oxidative stress promotes metabolic rewiring to maintain redox balance in HER2+ breast tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Jewish General Hospital; McGill University","funders":"","keywords":"Breast cancer; Oxidative stress; Reactive oxygen species; Cancer research; Tumor microenvironment; Cancer; In vivo; Glycolysis; Biology; Medicine; Internal medicine; Metabolism; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008572898,0.0002145131,0.0002153897,0.0001143319,0.000162305,0.0003191607,0.0001495904,0.0002345091,0.002376907],"category_scores_gemma":[0.00005923752,0.00008705074,0.0002021111,0.0001497837,0.00016785,0.0001788423,0.0002071425,0.0004844237,0.0003501074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002409356,"about_ca_system_score_gemma":0.0001699105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000412395,"about_ca_topic_score_gemma":0.0005681961,"domain_scores_codex":[0.9999167,0.000009498666,0.000005370704,0.00001747049,0.00001881506,0.00003218237],"domain_scores_gemma":[0.9999489,0.000004588569,0.00001386417,0.000005457282,0.000006184831,0.00002100905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001545112,0.00004051592,0.0005639216,0.00002385022,0.000004027171,0.00004649681,0.00000808931,0.00004920779,0.9979773,0.00008380703,0.0001169435,0.0009312808],"study_design_scores_gemma":[0.00003518421,0.0008101465,0.03092589,0.00001042032,0.00001940022,0.0004386953,0.0001098583,0.001257751,0.9599637,0.0001986645,0.006221213,0.000009035183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958098,0.0008671444,0.001379598,0.00022301,0.00005287767,0.00001782045,0.0005810944,0.00004745591,0.001021234],"genre_scores_gemma":[0.9939585,0.00054103,0.001070259,0.0001523152,0.00001670396,0.00003222721,0.0009499416,0.00001955315,0.003259368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002376907,"threshold_uncertainty_score":0.007951558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0370156100722128,"score_gpt":0.3635064074765537,"score_spread":0.3264907974043409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}