{"id":"W4362596072","doi":"10.1158/1538-7445.am2023-3099","title":"Abstract 3099: Hnd-01: a potent inhibitor of wild type mutant BTK","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Bruton's tyrosine kinase; Ibrutinib; Dasatinib; Tyrosine kinase; Cancer research; Chemistry; Chronic lymphocytic leukemia; LYN; Pharmacology; breakpoint cluster region; Biology; Biochemistry; Signal transduction; Leukemia; Receptor; Immunology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009272666,0.0004098582,0.0002991993,0.0002667679,0.0001454149,0.0002431937,0.0004082879,0.0003023669,0.002893323],"category_scores_gemma":[0.00005321308,0.000123902,0.0002287343,0.0002575714,0.0001493526,0.0002035709,0.0001864674,0.0007336742,0.001560965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003900935,"about_ca_system_score_gemma":0.0003821728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007023665,"about_ca_topic_score_gemma":0.001078497,"domain_scores_codex":[0.9999055,0.000009716155,0.00001023079,0.00002112406,0.00002615638,0.00002731342],"domain_scores_gemma":[0.9999756,0.000001932714,0.000004032538,0.000002219897,0.00000461575,0.00001159918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001278831,0.0008076561,0.000660887,0.0004272655,0.00005504171,0.0009228069,0.00002986812,0.0006593859,0.9397415,0.0009054817,0.00736182,0.04714964],"study_design_scores_gemma":[0.001811594,0.008231007,0.006709204,0.00003539879,0.0001223056,0.007611995,0.00003077129,0.002970839,0.8749263,0.0002741388,0.09721839,0.00005804064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9192948,0.02763513,0.007744279,0.001567977,0.001184968,0.0005794768,0.006227937,0.0009751486,0.03479033],"genre_scores_gemma":[0.9523461,0.008660366,0.004509732,0.0006143755,0.00007453387,0.000166981,0.006438965,0.00003559471,0.02715331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002893323,"threshold_uncertainty_score":0.009679139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.122556774424715,"score_gpt":0.4454052791664881,"score_spread":0.3228485047417731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}