{"id":"W4362596323","doi":"10.1158/1538-7445.am2023-4753","title":"Abstract 4753: LSD1 &8211mediated FOXA2/AP1 transcription program drives lineage plasticity in prostate cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"FOXA2; FOXA1; Transcription factor; Biology; Chromatin; Cancer research; Carcinogenesis; Cell biology; Computational biology; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001000385,0.0002117658,0.0001436786,0.000216939,0.0002609441,0.0002739308,0.0001657477,0.0002028916,0.004287391],"category_scores_gemma":[0.00004397199,0.0001110437,0.0002177615,0.0001622999,0.000314569,0.0001856662,0.0002729126,0.0005481552,0.001044017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003996251,"about_ca_system_score_gemma":0.0003873991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001103102,"about_ca_topic_score_gemma":0.001578032,"domain_scores_codex":[0.99992,0.000009194749,0.000005123821,0.00002154374,0.00002031677,0.00002387139],"domain_scores_gemma":[0.9999491,0.000006096529,0.00001009315,0.000007215585,0.00000515214,0.00002235517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001088879,0.00003510773,0.0006682515,0.00006786645,0.000005692439,0.0001068886,0.00002417643,0.00008091656,0.9965313,0.0004014016,0.0003049313,0.001664453],"study_design_scores_gemma":[0.00002476955,0.0002621326,0.01347232,0.000009750942,0.00001614083,0.0005032397,0.000119813,0.001273741,0.9758783,0.0001588442,0.00827293,0.000007992236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849344,0.002218084,0.004424303,0.0002803238,0.00006065134,0.00002950852,0.001401997,0.0002638343,0.006386837],"genre_scores_gemma":[0.9906465,0.0006115625,0.0009628793,0.00007818681,0.000009333845,0.00002867994,0.000816496,0.00002519081,0.006821234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004287391,"threshold_uncertainty_score":0.01434273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1491944232581934,"score_gpt":0.4747075890183594,"score_spread":0.325513165760166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}