{"id":"W4362596417","doi":"10.1158/1538-7445.am2023-2931","title":"Abstract 2931: Functional characterization of KJ-103, a novel therapeutic anti-TROP2 heavy chain-only antibody","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"In vivo; Cancer research; Antibody-dependent cell-mediated cytotoxicity; Pancreatic cancer; CD47; Cancer; Immune system; Antibody; Tumor microenvironment; Metastasis; Cancer cell; Immunology; Medicine; Biology; Internal medicine; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001559813,0.0003165519,0.0001882284,0.0001709551,0.0001178258,0.0001925827,0.000229819,0.0003350018,0.002339271],"category_scores_gemma":[0.0001901631,0.00008735343,0.0002113513,0.0001388959,0.0001052872,0.0001491107,0.00008766193,0.0003787095,0.0008999817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002552346,"about_ca_system_score_gemma":0.0001743607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008643394,"about_ca_topic_score_gemma":0.0003891035,"domain_scores_codex":[0.9998884,0.00001943117,0.000007480996,0.00001711942,0.00003901223,0.00002855072],"domain_scores_gemma":[0.9999077,0.00001952063,0.0000126119,0.000007861619,0.00002893018,0.00002325239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001223993,0.00006841011,0.0001420306,0.00001688876,0.000002653092,0.00004849842,0.000007106749,0.0001155079,0.998062,0.00003226698,0.00006655078,0.001315677],"study_design_scores_gemma":[0.00006175158,0.001226851,0.005826646,0.000008694374,0.00002099547,0.000939861,0.00002052686,0.002800022,0.9850069,0.00006022971,0.004020442,0.000007175934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897438,0.00119543,0.004052621,0.0001191366,0.00002648225,0.0001093754,0.0007822575,0.00006185299,0.003909136],"genre_scores_gemma":[0.9893246,0.000557221,0.002651559,0.0001516162,0.00001463581,0.0000673298,0.002943501,0.00003203362,0.004257522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002339271,"threshold_uncertainty_score":0.007825673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.143660461997313,"score_gpt":0.4370772311070142,"score_spread":0.2934167691097012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}