{"id":"W4362596546","doi":"10.1158/1538-7445.am2023-3522","title":"Abstract 3522: DICER1 Platform domain missense variants led to tumor susceptibility via failure of precursor miRNA binding","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Congenital Diaphragmatic Hernia Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Missense mutation; Germline; microRNA; Ribonuclease III; Biology; Genetics; Germline mutation; Dicer; Loss function; RNase H; Heteroduplex; Cancer research; Phenotype; Mutation; RNase P; Gene; RNA; RNA interference","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001423124,0.0007423596,0.0003420465,0.0008125312,0.0004918058,0.0002864663,0.0003589513,0.001108904,0.004718665],"category_scores_gemma":[0.000584062,0.0002098417,0.0004640841,0.0003547766,0.0003761567,0.0001330248,0.0004590228,0.0006008089,0.0006013926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002814461,"about_ca_system_score_gemma":0.000159087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001246263,"about_ca_topic_score_gemma":0.0009772801,"domain_scores_codex":[0.999744,0.0000291819,0.00003526212,0.00009592214,0.00005576801,0.0000398724],"domain_scores_gemma":[0.9996442,0.0001259867,0.00006241441,0.00002333013,0.00002845463,0.0001156166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006102755,0.0002241091,0.01576219,0.0001003418,0.00007789164,0.2535358,0.0005867465,0.0004752486,0.7229679,0.0006678262,0.0004631278,0.004528482],"study_design_scores_gemma":[0.0001163562,0.001719901,0.1303208,0.00004069095,0.0001427236,0.6255692,0.0003649199,0.003479165,0.2311829,0.0004116517,0.00655925,0.00009252447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966742,0.000190305,0.001127796,0.0001141,0.00004251092,0.00004646569,0.0004869838,0.00007016404,0.001247474],"genre_scores_gemma":[0.9979727,0.00006488612,0.0004875263,0.00005018575,0.00001252651,0.000008551426,0.0002376637,0.00002464959,0.001141322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004718665,"threshold_uncertainty_score":0.01578552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09049279366590288,"score_gpt":0.4137862380920894,"score_spread":0.3232934444261866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}