{"id":"W4362601138","doi":"10.1083/jcb.202204001","title":"Oncogenic signaling is coupled to colorectal cancer cell differentiation state","year":2023,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Berlin Institute of Health; University of Toronto; Deutsche Forschungsgemeinschaft; Robert Koch Institut; F. Hoffmann-La Roche","keywords":"Biology; KRAS; Transcriptome; Colorectal cancer; Cellular differentiation; Cancer stem cell; Cancer research; Cancer; Cancer cell; Tumor progression; Phenotype; Signal transduction; Cell signaling; Genetics; Cell biology; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000702926,0.00009227477,0.0001651445,0.0003073522,0.0001494883,0.0004351632,0.00007624369,0.0001288331,0.0006205214],"category_scores_gemma":[0.0001613732,0.0001402245,0.00009776014,0.0002560763,0.0001724479,0.0001752048,0.0001762539,0.0002683442,0.0002039665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002783999,"about_ca_system_score_gemma":0.0001676412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007955119,"about_ca_topic_score_gemma":0.001546971,"domain_scores_codex":[0.9999107,0.000008807099,0.000005087033,0.00003102705,0.000028627,0.00001575546],"domain_scores_gemma":[0.9998775,0.0000271073,0.00003487939,0.00001403652,0.00002239602,0.00002406512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003224266,0.000002687187,0.001725717,0.000008996757,0.000001739461,0.0000125833,0.00002101254,0.0001499538,0.9970483,0.00008765676,0.0000112623,0.0008978359],"study_design_scores_gemma":[0.00000448743,0.00008869074,0.09855352,0.00000472769,0.00001550931,0.0001800662,0.0001521566,0.004495029,0.8948787,0.0002961522,0.001320086,0.00001091986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958097,0.0001798586,0.002928719,0.00002809721,0.000003121012,0.000006290271,0.0003439226,0.00005494685,0.0006454476],"genre_scores_gemma":[0.997148,0.0002009969,0.00181342,0.00001812688,0.000001914345,0.00001154364,0.0003272048,0.00001507882,0.0004638778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007955119,"threshold_uncertainty_score":0.002075851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009371268501661922,"score_gpt":0.2554163500793116,"score_spread":0.2460450815776496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}