{"id":"W4362601138","doi":"10.1083/jcb.202204001","title":"Oncogenic signaling is coupled to colorectal cancer cell differentiation state","year":2023,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Berlin Institute of Health; University of Toronto; Deutsche Forschungsgemeinschaft; Robert Koch Institut; F. Hoffmann-La Roche","keywords":"Biology; KRAS; Transcriptome; Colorectal cancer; Cellular differentiation; Cancer stem cell; Cancer research; Cancer; Cancer cell; Tumor progression; Phenotype; Signal transduction; Cell signaling; Genetics; Cell biology; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003053869,0.0001022326,0.0001532876,0.00004139529,0.00006420616,0.0000114182,0.0002282151,0.00007715879,0.0000833683],"category_scores_gemma":[0.00003241397,0.00007224055,0.00009061547,0.00009909215,0.00003353155,0.000001942838,0.00009862777,0.00008860117,0.00003137733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004136548,"about_ca_system_score_gemma":0.0001467915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001097442,"about_ca_topic_score_gemma":0.0001063696,"domain_scores_codex":[0.9992763,0.00006784806,0.000267852,0.0001085428,0.00007025319,0.0002091354],"domain_scores_gemma":[0.9993495,0.00007986429,0.0002264204,0.0001153316,0.0001511912,0.0000776875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002626746,0.00002186153,0.0004974366,0.000006006536,0.00004243958,0.000001420736,0.0002257506,0.002127783,0.9935077,0.000001906479,0.002738527,0.0005664449],"study_design_scores_gemma":[0.0005137953,0.0006679005,0.001193706,0.000005326726,0.00005040774,0.000004801003,0.00009534521,0.0003299749,0.9884484,0.0001366674,0.008452744,0.0001009153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966879,0.00139226,0.0008093521,0.0003054994,0.0005153735,0.0001043714,0.00005287956,0.000003634088,0.0001287535],"genre_scores_gemma":[0.992685,0.005923572,0.00006577968,0.000587922,0.0003473932,0.000004488854,0.00002251965,0.00001509322,0.0003482656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005714217,"threshold_uncertainty_score":0.2945884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009371268501661922,"score_gpt":0.2554163500793116,"score_spread":0.2460450815776496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}