{"id":"W4362602865","doi":"10.1093/ehjcvp/pvad025","title":"Vascular mechanisms of post-COVID-19 conditions: Rho-kinase is a novel target for therapy","year":2023,"lang":"en","type":"article","venue":"European Heart Journal - Cardiovascular Pharmacotherapy","topic":"Long-Term Effects of COVID-19","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institutes of Health; University of Glasgow; Tenovus; Wellcome Trust; Chief Scientist Office; Cancer Research UK; UK Research and Innovation; Scottish Government; British Heart Foundation; Medical Research Council; International Seafood Sustainability Foundation; NHS Greater Glasgow and Clyde; Johns Hopkins University; Cisco Systems","keywords":"Medicine; Fasudil; Vasoconstriction; Internal medicine; Sirius Red; Histopathology; Electrical impedance myography; Endothelial dysfunction; RHOA; Rho-associated protein kinase; Gastroenterology; Endocrinology; Pathology; Vasodilation; Immunohistochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000332524,0.0002780739,0.0004995469,0.0001491152,0.0001832594,0.0005711167,0.0002273425,0.0004069944,0.001748606],"category_scores_gemma":[0.0002985846,0.00006218609,0.0003688125,0.0001286861,0.0002759684,0.0002467391,0.0002744803,0.000633824,0.0003341865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002481229,"about_ca_system_score_gemma":0.0003217796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001378225,"about_ca_topic_score_gemma":0.0003159142,"domain_scores_codex":[0.9998729,0.00003395426,0.00001116607,0.00001917869,0.00001761423,0.00004510563],"domain_scores_gemma":[0.9998301,0.00002045035,0.00007455829,0.00001571615,0.00002257641,0.00003652163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01462,0.00135732,0.1420988,0.002513952,0.0006614083,0.006167088,0.0003292627,0.00054587,0.465032,0.003121451,0.008168144,0.3553847],"study_design_scores_gemma":[0.001207217,0.01081863,0.7828914,0.001468549,0.001069346,0.02371443,0.001448693,0.003515491,0.09688549,0.003250875,0.07365046,0.00007939091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8872141,0.09861343,0.003295901,0.004179102,0.0003268826,0.000102803,0.0004171493,0.0001073945,0.005743233],"genre_scores_gemma":[0.9783585,0.01703826,0.001499589,0.0006594337,0.0004399459,0.00008677947,0.0005211752,0.00001122917,0.001385242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001748606,"threshold_uncertainty_score":0.0058496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05154086754211451,"score_gpt":0.3601143848326227,"score_spread":0.3085735172905082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}