{"id":"W4362602865","doi":"10.1093/ehjcvp/pvad025","title":"Vascular mechanisms of post-COVID-19 conditions: Rho-kinase is a novel target for therapy","year":2023,"lang":"en","type":"article","venue":"European Heart Journal - Cardiovascular Pharmacotherapy","topic":"Long-Term Effects of COVID-19","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institutes of Health; University of Glasgow; Tenovus; Wellcome Trust; Chief Scientist Office; Cancer Research UK; UK Research and Innovation; Scottish Government; British Heart Foundation; Medical Research Council; International Seafood Sustainability Foundation; NHS Greater Glasgow and Clyde; Johns Hopkins University; Cisco Systems","keywords":"Medicine; Fasudil; Vasoconstriction; Internal medicine; Sirius Red; Histopathology; Electrical impedance myography; Endothelial dysfunction; RHOA; Rho-associated protein kinase; Gastroenterology; Endocrinology; Pathology; Vasodilation; Immunohistochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00675434,0.0006187434,0.001387678,0.0009279628,0.000570382,0.0001262057,0.0005348638,0.0001296505,0.0009349893],"category_scores_gemma":[0.0007011259,0.0005401843,0.005080313,0.0009197446,0.0001833818,0.0003344176,0.00007703065,0.0006675025,0.0002366554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000272786,"about_ca_system_score_gemma":0.000814109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003489669,"about_ca_topic_score_gemma":2.521207e-7,"domain_scores_codex":[0.9945629,0.001192257,0.0009811608,0.0007798635,0.001593729,0.0008901035],"domain_scores_gemma":[0.9958944,0.0006441739,0.0003155946,0.001178885,0.000708563,0.001258437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001948847,0.0007228549,0.0006148697,0.0009802695,0.0159821,0.001528659,0.001733037,0.003377744,0.9069616,0.0002264331,0.06024463,0.005678984],"study_design_scores_gemma":[0.03538305,0.002002246,0.003688301,0.0002986132,0.001051177,0.00239974,0.0001944757,0.0006767373,0.1035608,0.001143122,0.8488002,0.0008014935],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.545435,0.0535706,0.3497351,0.03186215,0.003832433,0.01193353,0.00126679,0.001606015,0.0007583334],"genre_scores_gemma":[0.7523772,0.03489172,0.03783356,0.1638187,0.006962932,0.0005142908,0.0006272231,0.00166162,0.001312818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8034008,"threshold_uncertainty_score":0.9999783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05154086754211451,"score_gpt":0.3601143848326227,"score_spread":0.3085735172905082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}