{"id":"W4362604086","doi":"10.1038/s41388-023-02680-z","title":"Chronic hypoxia favours adoption to a castration-resistant cell state in prostate cancer","year":2023,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Institute for Research in Immunology and Cancer; Princess Margaret Cancer Centre","funders":"CIHR Skin Research Training Centre; Ontario Institute for Cancer Research; Government of Canada; Canadian Institutes of Health Research; Government of Ontario; Princess Margaret Cancer Foundation","keywords":"Prostate cancer; Biology; GLUT1; Hypoxia (environmental); Androgen; Prostate; Cancer research; Androgen deprivation therapy; Cancer; Tramp; Cancer cell; Internal medicine; Oncology; Glucose transporter; Endocrinology; Medicine; Hormone; Genetics; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009546133,0.00008232631,0.0001872358,0.0001652919,0.0002176199,0.0003865827,0.0001096498,0.0001983863,0.001287701],"category_scores_gemma":[0.0001061943,0.00008667858,0.00009174666,0.000157124,0.0002718667,0.0001593243,0.0002153379,0.000289544,0.0001213535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003061208,"about_ca_system_score_gemma":0.0002690581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001499876,"about_ca_topic_score_gemma":0.002012073,"domain_scores_codex":[0.9999286,0.00001143942,0.000003800445,0.00001369012,0.00001868656,0.00002371949],"domain_scores_gemma":[0.9998971,0.00001199379,0.00003397345,0.000005762719,0.000009554791,0.00004158796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006425735,0.00007969925,0.01782241,0.0001384954,0.00002020932,0.0002510707,0.0001291786,0.0002574745,0.9742122,0.0005036782,0.000251397,0.005691586],"study_design_scores_gemma":[0.00004402695,0.00323629,0.6388997,0.00003170937,0.00005716762,0.003015994,0.0006464871,0.002865893,0.3426591,0.0007096183,0.007806692,0.00002726634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949227,0.003002451,0.0008985308,0.0001340611,0.00001595957,0.00001340984,0.0001312634,0.00003322567,0.0008483712],"genre_scores_gemma":[0.9990091,0.0004655969,0.0001650002,0.00002907503,0.000006906269,0.000004322055,0.00005856405,0.000002435336,0.0002590157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001499876,"threshold_uncertainty_score":0.004307806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01201042071137748,"score_gpt":0.2704716325440797,"score_spread":0.2584612118327023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}