{"id":"W4362606390","doi":"10.1038/s41586-023-05874-3","title":"Lung adenocarcinoma promotion by air pollutants","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Air Quality and Health Impacts","field":"Environmental Science","cited_by":761,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Vancouver Coastal Health; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"Linda Crnic Institute for Down Syndrome, University of Colorado School of Medicine, Anschutz Medical Campus; National Cancer Institute; Japan Society for the Promotion of Science; Engineering and Physical Sciences Research Council; Horizon 2020 Framework Programme; Genentech; Peking University People's Hospital; Ono Pharmaceutical; University College London Hospitals NHS Foundation Trust; Chinese Academy of Medical Sciences; Medical Research Council; National Research Foundation of Korea; Cancerfonden; Vetenskapsrådet; National Natural Science Foundation of China; Peking University; Chang Gung Medical Foundation; National Institute for Health and Care Research; AstraZeneca; Invitae; Revolution Medicines; Astex Pharmaceuticals; LifeArc; Francis Crick Institute; Wellcome Trust; Cancer Research UK; University College London; Stand Up To Cancer; Ministry of Science and ICT, South Korea; LUNGevity Foundation; Entertainment Industry Foundation; Bristol-Myers Squibb; European Respiratory Society; Pfizer; National Institutes of Health; Rosetrees Trust; European Commission; Breast Cancer Research Foundation; National Research Foundation; Amgen; American Association for Cancer Research; Génome Québec; Korea Health Industry Development Institute; International Association for the Study of Lung Cancer; U.S. Department of Veterans Affairs","keywords":"Lung cancer; KRAS; Carcinogenesis; Cancer research; Lung; Adenocarcinoma; Medicine; Carcinogen; Cancer; Immunology; Oncology; Biology; Internal medicine; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002587534,0.00007693066,0.00007447176,0.00002214112,0.0001433984,0.000009110196,0.0001343722,0.0005659778,0.001176981],"category_scores_gemma":[0.00008040264,0.00006742172,0.00002318358,0.0004038047,0.00004084661,0.0001589398,0.00007136709,0.0008114952,0.001696717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001283026,"about_ca_system_score_gemma":0.00001133424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000396445,"about_ca_topic_score_gemma":0.00002750425,"domain_scores_codex":[0.9990559,0.00004284512,0.00009941494,0.0001931775,0.0003012357,0.00030739],"domain_scores_gemma":[0.999651,0.00002347599,0.00003675649,0.0001466807,0.000002820798,0.0001393174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.00001218,0.00003650425,0.03707183,0.00002905468,0.00000338459,0.00001116377,0.0006205689,0.00002121728,0.001297367,0.0001035026,0.9386208,0.02217242],"study_design_scores_gemma":[0.000217498,0.00006637935,0.9404195,0.00001508876,0.000004829221,0.000005745969,0.0000693477,0.002393959,0.0008127516,0.0005709176,0.05529009,0.0001339211],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9438647,0.000416086,0.00002829085,0.04781478,0.0003489788,0.0002986373,0.00009016132,0.0002621037,0.006876245],"genre_scores_gemma":[0.9890003,0.00002330407,0.00006939704,0.006817807,0.00006274299,0.000004859126,0.00002072987,0.000009928031,0.003990915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9033476,"threshold_uncertainty_score":0.9997361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01987857508886128,"score_gpt":0.3101488921918295,"score_spread":0.2902703171029682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}