{"id":"W4362608498","doi":"10.1038/s41598-023-31905-0","title":"Impaired retinoic acid signaling in cerebral cavernous malformations","year":2023,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Vascular Malformations Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"HORIZON EUROPE Marie Sklodowska-Curie Actions; Universität Potsdam; Agence Nationale de la Recherche; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Fondation Leducq; Deutsche Forschungsgemeinschaft","keywords":"Retinoic acid; Zebrafish; Medicine; Biology; Tretinoin; Phenotype; Central nervous system; Retinoic acid receptor; Cancer research; Pharmacology; Internal medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001400253,0.0002921729,0.0003229734,0.0005579681,0.0002410796,0.0003256397,0.0002628837,0.0004416876,0.001201789],"category_scores_gemma":[0.0001575059,0.0001728926,0.0003259758,0.0001901936,0.0004756158,0.0002487805,0.0002745691,0.0007947649,0.0002192219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005424349,"about_ca_system_score_gemma":0.0004433621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002398225,"about_ca_topic_score_gemma":0.003000919,"domain_scores_codex":[0.9997796,0.0000238389,0.00002413295,0.00006525224,0.00006548659,0.00004179769],"domain_scores_gemma":[0.9998203,0.00002354088,0.00006862429,0.00002187632,0.0000199015,0.00004575162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008409074,0.000007906418,0.000262809,0.00002151316,0.000007406187,0.0001994347,0.00001697309,0.00006001538,0.9983549,0.0001234409,0.00002311045,0.000838433],"study_design_scores_gemma":[0.00001801859,0.0001572949,0.008078706,0.000008079865,0.00003701089,0.001027094,0.00005203623,0.0005884222,0.9878916,0.0001187588,0.00201216,0.00001083237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929523,0.002369727,0.002750539,0.000165937,0.00003374495,0.00001583476,0.0004194042,0.00009045089,0.001202011],"genre_scores_gemma":[0.9951215,0.001415721,0.001301726,0.00004866755,0.0000059991,0.00002254301,0.0002824778,0.00002360444,0.001777705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002398225,"threshold_uncertainty_score":0.00476861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02265638686868379,"score_gpt":0.2677754016501254,"score_spread":0.2451190147814416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}