{"id":"W4362616240","doi":"10.3390/antiox12040883","title":"Acute Kidney Injury Induces Oxidative Stress and Hepatic Lipid Accumulation through AMPK Signaling Pathway","year":2023,"lang":"en","type":"article","venue":"Antioxidants","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; University of Manitoba; St. Boniface Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Fondation de l’Hôpital Saint-Boniface","keywords":"Lipogenesis; Internal medicine; Endocrinology; AMPK; Lipid metabolism; Oxidative stress; Steatosis; Liver injury; AMP-activated protein kinase; Kidney; Chemistry; Protein kinase A; Biology; Medicine; Biochemistry; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001938929,0.000577856,0.0007165078,0.0004811316,0.0003333226,0.0004138625,0.0001861487,0.000469744,0.001414297],"category_scores_gemma":[0.0001236809,0.0002410555,0.0007708391,0.000356191,0.0002182117,0.0003305864,0.000354638,0.0009781832,0.0002806302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000278998,"about_ca_system_score_gemma":0.0003959415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002948205,"about_ca_topic_score_gemma":0.0004438385,"domain_scores_codex":[0.9997492,0.00003597247,0.0000357072,0.000039679,0.0000555804,0.00008378204],"domain_scores_gemma":[0.9998775,0.000007266486,0.0000497203,0.000007753286,0.0000282718,0.00002961218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001177354,0.0002672889,0.001799032,0.0007597316,0.0001191319,0.0004554866,0.00006311649,0.0002179375,0.9875252,0.0002734978,0.0003462493,0.006996073],"study_design_scores_gemma":[0.0003844171,0.003383205,0.09705392,0.0001787937,0.0005041162,0.002126402,0.0003641669,0.004007268,0.8786014,0.001803687,0.01151479,0.00007780043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600411,0.02855469,0.006587608,0.0008382866,0.0003157067,0.0001131677,0.0005189526,0.0001888487,0.00284161],"genre_scores_gemma":[0.9811736,0.01190692,0.002872126,0.0004814503,0.000104544,0.0001782653,0.0008447502,0.00001589715,0.00242252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001414297,"threshold_uncertainty_score":0.004731297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04398011282646333,"score_gpt":0.3333220119246234,"score_spread":0.28934189909816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}