{"id":"W4362632481","doi":"10.1016/j.celrep.2023.112338","title":"Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Institute of Genetics; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Cancer Research Society; National Institute of General Medical Sciences; American Heart Association; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; W. M. Keck Foundation","keywords":"Intravasation; Extracellular matrix; Cell biology; Alternative splicing; Cancer research; Stiffening; Biology; Cancer cell; Cancer; Genetics; Materials science; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001533536,0.0001589421,0.0001077737,0.0001796994,0.0001179112,0.0002820801,0.00007452694,0.0001101257,0.000726048],"category_scores_gemma":[0.0001493293,0.0001185532,0.0001553509,0.00008649222,0.0001633011,0.0001531734,0.0001550631,0.000221791,0.0001408877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001465342,"about_ca_system_score_gemma":0.0001063971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002429471,"about_ca_topic_score_gemma":0.0005439314,"domain_scores_codex":[0.9999005,0.00002383748,0.000007836957,0.00002443971,0.00002486685,0.00001842063],"domain_scores_gemma":[0.9998678,0.00003075469,0.00005749225,0.000009290191,0.00001178118,0.00002284453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003051731,0.000004734564,0.0008743118,0.000008867451,0.000003118161,0.00003962127,0.00001236462,0.00004683358,0.9983661,0.00006691987,0.000009358144,0.0005373621],"study_design_scores_gemma":[0.000007938813,0.0001199765,0.0469497,0.000003826513,0.00001532636,0.0003822268,0.00006426144,0.001547977,0.9496467,0.0001253921,0.001130665,0.000006065492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969494,0.0005878616,0.001778066,0.000052078,0.000006670766,0.0000055002,0.00009449787,0.00002311542,0.0005029278],"genre_scores_gemma":[0.9979286,0.0003341901,0.0009313673,0.00001875318,0.000003578057,0.000006818959,0.0001093896,0.000006445215,0.0006608506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000726048,"threshold_uncertainty_score":0.002428889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00885238041395689,"score_gpt":0.2512327648215916,"score_spread":0.2423803844076347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}