{"id":"W4362634868","doi":"10.3390/cells12071083","title":"α-Synuclein Preformed Fibrils Bind to β-Neurexins and Impair β-Neurexin-Mediated Presynaptic Organization","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"PROTEO; Université du Québec à Montréal; McGill University; Montreal Neurological Institute and Hospital; Université de Montréal; Montreal Clinical Research Institute","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canada First Research Excellence Fund; Université de Montréal; Parkinson Society Canada; Canadian Institutes of Health Research; Parkinson Canada; Alzheimer Society; McGill University","keywords":"Neurexin; Fibril; Neuroscience; Cell biology; Chemistry; Biophysics; Biology; Postsynaptic potential; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00008815092,0.0001992774,0.0002582353,0.0002258639,0.0001005261,0.0000364993,0.00006983505,0.00009838381,0.0002584975],"category_scores_gemma":[0.0001241743,0.0001659931,0.0000445834,0.000828979,0.00002713787,0.00008154168,0.00009468728,0.00007903381,0.001715183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006790211,"about_ca_system_score_gemma":0.00008078868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001718856,"about_ca_topic_score_gemma":0.000004020457,"domain_scores_codex":[0.9987634,0.00003192,0.0001953356,0.0003986624,0.0002469143,0.0003637862],"domain_scores_gemma":[0.999052,0.00006065613,0.00005106001,0.0002955165,0.00008053872,0.0004602575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005599809,0.0007578311,0.04394835,0.0005332286,0.0005700747,0.001193415,0.001836124,0.0001040926,0.9152604,0.0001511589,0.02954671,0.005538591],"study_design_scores_gemma":[0.005488247,0.002090689,0.6535921,0.0002265677,0.0005248705,0.00008532146,0.0002602758,0.002158699,0.2916918,0.0002597748,0.04299393,0.0006277624],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973118,0.00006065406,0.00004423305,0.0006961972,0.000203883,0.0007643729,0.00008337929,0.0003553685,0.0004800525],"genre_scores_gemma":[0.9967521,0.0001061539,0.0002142934,0.0005134897,0.00008290103,0.00003088872,0.0002333247,0.00006336714,0.00200348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6235687,"threshold_uncertainty_score":0.9990621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01201695024056773,"score_gpt":0.241466329824567,"score_spread":0.2294493795839993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}