{"id":"W4362635636","doi":"10.1038/s41467-023-37339-6","title":"Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Ontario Ministry of Research and Innovation; National Institutes of Health; Hospital for Sick Children; University of Toronto; Canada First Research Excellence Fund; Canada Research Chairs; National Institute of General Medical Sciences; Ontario Brain Institute; Canadian Institutes of Health Research; Genome Canada","keywords":"Rett syndrome; Transcription (linguistics); MECP2; Gene; Biology; Messenger RNA; Gene expression; microRNA; Transcription factor; Regulation of gene expression; Transcriptional regulation; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003239101,0.0005121214,0.0005235972,0.0004409813,0.00016234,0.0004303809,0.0003170647,0.000329504,0.0005992254],"category_scores_gemma":[0.001223497,0.0002145538,0.0004176119,0.0002769191,0.0003188693,0.0003597464,0.0002136597,0.0004573665,0.0002051279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003358569,"about_ca_system_score_gemma":0.0001804478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008608113,"about_ca_topic_score_gemma":0.001159626,"domain_scores_codex":[0.9997895,0.00003051472,0.00001414828,0.00007977982,0.00005956519,0.00002643535],"domain_scores_gemma":[0.9991842,0.0002481343,0.0003542094,0.0001024423,0.00005029625,0.00006071557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005331496,0.00004739415,0.04961818,0.00006576801,0.00009907375,0.0003532703,0.00006293128,0.01631697,0.9188605,0.001041756,0.0002079367,0.01279324],"study_design_scores_gemma":[0.00004405128,0.0009016692,0.2697595,0.00003207444,0.0002051824,0.002864144,0.0001050691,0.2504857,0.461691,0.01128982,0.002494399,0.0001274181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589761,0.0005068804,0.03879813,0.00008464079,0.00001209312,0.00001240106,0.0006010284,0.0004716083,0.0005370646],"genre_scores_gemma":[0.9928997,0.0001726811,0.005865394,0.00003567555,0.000008300761,0.00002685228,0.0005760975,0.00008309953,0.000332221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008608113,"threshold_uncertainty_score":0.002436817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02542697984953168,"score_gpt":0.2678362379025193,"score_spread":0.2424092580529876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}