{"id":"W4362635829","doi":"10.1055/a-2069-4552","title":"Stereoselective Total Synthesis of Stereoisomers of Entecavir","year":2023,"lang":"en","type":"article","venue":"Synthesis","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Micropharma (Canada)","funders":"","keywords":"Chemistry; Entecavir; Stereoselectivity; Total synthesis; Stereochemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003708706,0.0006943071,0.0004438605,0.0004688656,0.0002970455,0.0003393514,0.0004893225,0.0002978284,0.006344841],"category_scores_gemma":[0.0002487342,0.0002799621,0.0003866673,0.0003284674,0.0002325644,0.0003558151,0.0004216092,0.0007601486,0.002342038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002831689,"about_ca_system_score_gemma":0.0006705406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003292399,"about_ca_topic_score_gemma":0.0007765975,"domain_scores_codex":[0.9997719,0.00003984683,0.00001977368,0.00004171279,0.00006043646,0.00006633267],"domain_scores_gemma":[0.9998574,0.00001444056,0.00002347855,0.00003102652,0.00004243505,0.00003117303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002826085,0.00008850201,0.0001249045,0.00019908,0.00002736998,0.0002515448,0.0001021437,0.000533097,0.9761142,0.002278983,0.0004705188,0.01952705],"study_design_scores_gemma":[0.00005855561,0.0004928312,0.0003957092,0.00001460849,0.00002830563,0.0002630304,0.00003419289,0.0003769909,0.9837272,0.0003881922,0.01420079,0.0000196502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7180677,0.00765359,0.1826298,0.0004663058,0.0005259495,0.001249489,0.004682328,0.001158622,0.08356623],"genre_scores_gemma":[0.9205337,0.005270735,0.05434062,0.0001945373,0.00005924972,0.0002946831,0.001769889,0.0001977869,0.01733876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006344841,"threshold_uncertainty_score":0.02122563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01441957984549526,"score_gpt":0.2593040710211023,"score_spread":0.244884491175607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}