{"id":"W4362639631","doi":"10.1139/cjc-2022-0276","title":"Synthesis, anticancer evaluation, and molecular docking study of some arylidenehydrazono analogues","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; MCF-7; Docking (animal); In vitro; Apoptosis; Cytotoxic T cell; Stereochemistry; Cell culture; Cancer cell; Enzyme; Human breast; Cytotoxicity; Structure–activity relationship; Biochemistry; Combinatorial chemistry; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005877212,0.0002699917,0.0003714093,0.00023264,0.0001169147,0.0001332011,0.0002514489,0.0001102728,0.001420667],"category_scores_gemma":[0.00006746738,0.00009448207,0.0001760441,0.0002887551,0.00009133369,0.0001005775,0.0001248686,0.0002373916,0.0002250416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001683257,"about_ca_system_score_gemma":0.0001970852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001471293,"about_ca_topic_score_gemma":0.003434355,"domain_scores_codex":[0.9999708,0.000004689895,0.000002495226,0.000005005,0.000008145857,0.000008857276],"domain_scores_gemma":[0.9999776,0.000002702894,0.000006899278,0.000001727316,0.000004867776,0.000006187829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004873684,0.0003558207,0.0006175814,0.0005683489,0.00003974097,0.0004523966,0.00004686304,0.01112027,0.9658151,0.0006574763,0.0004487971,0.01939034],"study_design_scores_gemma":[0.0003516835,0.005690033,0.008435014,0.00005951368,0.0002126587,0.0008028021,0.0001095261,0.01761122,0.9448336,0.0002308069,0.02159653,0.00006668783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778572,0.009092267,0.005437163,0.0001690291,0.00005927926,0.0001240944,0.0008568267,0.0001667276,0.006237371],"genre_scores_gemma":[0.9816534,0.007013525,0.006775022,0.00005622513,0.00001211192,0.00007363076,0.0007277159,0.00001340502,0.003674904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001471293,"threshold_uncertainty_score":0.004752636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02876382622227999,"score_gpt":0.267198035778359,"score_spread":0.2384342095560791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}