{"id":"W4362644405","doi":"10.2139/ssrn.4406061","title":"Amphiphilic Tribasic Galactosamines Potentiate Rifampicin in Gram-Negative Bacteria at Low Mg++/Ca++Concentrations","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Rifampicin; Bacteria; Amphiphile; Chemistry; Microbiology; Gram; Gram-negative bacteria; Biochemistry; Biology; Antibiotics; Organic chemistry; Escherichia coli; Polymer; Genetics; Copolymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001876344,0.0003963386,0.0004045951,0.000142962,0.0001009587,0.0002906335,0.0001780634,0.0003630842,0.001894953],"category_scores_gemma":[0.0003208447,0.0001714461,0.000181654,0.0001349221,0.0002994336,0.0001752165,0.0003019797,0.0003857483,0.0005349322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001727283,"about_ca_system_score_gemma":0.0001846861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009156591,"about_ca_topic_score_gemma":0.001036833,"domain_scores_codex":[0.999716,0.00006787504,0.00002379464,0.00003142885,0.00007993936,0.00008083663],"domain_scores_gemma":[0.999741,0.00007624276,0.00005519514,0.00003094277,0.00002809617,0.0000684343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002524545,0.00001375755,0.00005137521,0.00004093965,0.000002013741,0.00003028907,0.00001455813,0.00002612356,0.9989166,0.00003809817,0.00003131319,0.0005823753],"study_design_scores_gemma":[0.00001672292,0.0002871112,0.00151064,0.000007560533,0.000005472271,0.00005599738,0.00002109078,0.0001458215,0.9972357,0.00002364789,0.0006872111,0.000003094465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938546,0.001775733,0.0007933048,0.0001511354,0.00004964391,0.00002687552,0.0002363032,0.0000712217,0.003041208],"genre_scores_gemma":[0.9970963,0.0003958728,0.0004673908,0.00004767863,0.00001439845,0.000009841519,0.0001403599,0.00001787685,0.001810286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001894953,"threshold_uncertainty_score":0.006339252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01381027581500499,"score_gpt":0.2469080568294041,"score_spread":0.2330977810143991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}