{"id":"W4362656994","doi":"10.1161/strokeaha.122.041854","title":"Vascular Risk Predicts Plasma Amyloid β 42/40 Through Cerebral Amyloid Burden in <i>Apolipoprotein E</i> ε4 Carriers","year":2023,"lang":"en","type":"article","venue":"Stroke","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Medicine; Dementia; Internal medicine; Cohort; Neuroimaging; Apolipoprotein E; Alzheimer's disease; Vascular dementia; Vascular disease; Cohort study; Stroke (engine); Disease; Pathology; Oncology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008106286,0.0005525677,0.0002626737,0.0005629542,0.0002979832,0.0006430332,0.0003363028,0.0005162851,0.002346995],"category_scores_gemma":[0.003568032,0.0002829789,0.0004151733,0.0003847,0.0003180335,0.0002727167,0.0002849993,0.0005024641,0.0003845519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001717501,"about_ca_system_score_gemma":0.0002130364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004806223,"about_ca_topic_score_gemma":0.003457542,"domain_scores_codex":[0.9998147,0.00006009242,0.0000172923,0.00005333447,0.00002211292,0.00003242457],"domain_scores_gemma":[0.998134,0.0004851407,0.0009172944,0.0001294873,0.0001003469,0.000233829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004193278,0.00006486212,0.997612,0.00000424482,0.00004821394,0.0001503219,0.00006586446,0.00006119858,0.000764789,0.00002507401,0.00007249265,0.0007115618],"study_design_scores_gemma":[0.00002506145,0.0002130471,0.9980561,0.000007102086,0.0001038275,0.0005340395,0.00007447698,0.0004919237,0.0002563687,0.0001037587,0.0001296698,0.000004722831],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996197,0.00003935491,0.00005761348,0.00002424708,0.000002775874,0.000003414181,0.00005515829,0.000003120487,0.0001945553],"genre_scores_gemma":[0.9995593,0.00003014893,0.0001174326,0.00001619287,0.000008368655,0.000005516082,0.00009383633,0.000002630257,0.0001665467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004806223,"threshold_uncertainty_score":0.009556472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01495064078244739,"score_gpt":0.2801794042941057,"score_spread":0.2652287635116583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}