{"id":"W4362657013","doi":"10.1002/alz.13066","title":"C1q is increased in cerebrospinal fluid‐derived extracellular vesicles in Alzheimer's disease: A multi‐cohort proteomics and immuno‐assay validation study","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Parkinson Vereinigung; GIESKES-STRIJBIS FONDS; Stichting Dioraphte; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer Nederland; Michael J. Fox Foundation for Parkinson's Research; ZonMw; Deutsche Forschungsgemeinschaft; European Commission; Roche Nederland; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Weston Brain Institute; Biogen","keywords":"Proteomics; Proteome; Biomarker; Cerebrospinal fluid; Cohort; Extracellular vesicles; Immune system; Medicine; Alzheimer's disease; Quantitative proteomics; Disease; Extracellular vesicle; Immunology; Microvesicles; Biology; Pathology; Bioinformatics; Cell biology; Biochemistry; microRNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002700082,0.0008319153,0.0005835212,0.001289082,0.001030396,0.00100273,0.0004964409,0.000762586,0.0009736375],"category_scores_gemma":[0.002826723,0.0003487997,0.0006253133,0.0006521915,0.0005310562,0.0003813817,0.001259286,0.0006268615,0.0002943262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006652242,"about_ca_system_score_gemma":0.0005896116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004211467,"about_ca_topic_score_gemma":0.002749158,"domain_scores_codex":[0.9990752,0.0001736302,0.00007471003,0.0003401806,0.0002392468,0.00009699873],"domain_scores_gemma":[0.9983528,0.0002998323,0.0004687405,0.0002570236,0.0004632233,0.0001583962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003587588,0.000386918,0.8727107,0.0001165361,0.00104375,0.0007079456,0.0008270856,0.0004281754,0.108762,0.0001278806,0.0006040689,0.01069743],"study_design_scores_gemma":[0.00005419437,0.0009974155,0.9788378,0.00002512717,0.0003495204,0.001993015,0.0002761298,0.000922928,0.01531248,0.0001068451,0.001089352,0.00003525553],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982413,0.0003262144,0.0006242188,0.00001980235,0.000008168805,0.00003003897,0.0005948509,0.00001219822,0.0001432132],"genre_scores_gemma":[0.997672,0.0001226269,0.0008635949,0.00003070741,0.000007819834,0.00004269385,0.0009338988,0.00001294984,0.0003136406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004211467,"threshold_uncertainty_score":0.01427954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02058550337610688,"score_gpt":0.2756549757590886,"score_spread":0.2550694723829817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}