{"id":"W4362657013","doi":"10.1002/alz.13066","title":"C1q is increased in cerebrospinal fluid‐derived extracellular vesicles in Alzheimer's disease: A multi‐cohort proteomics and immuno‐assay validation study","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Parkinson Vereinigung; GIESKES-STRIJBIS FONDS; Stichting Dioraphte; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer Nederland; Michael J. Fox Foundation for Parkinson's Research; ZonMw; Deutsche Forschungsgemeinschaft; European Commission; Roche Nederland; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Weston Brain Institute; Biogen","keywords":"Proteomics; Proteome; Biomarker; Cerebrospinal fluid; Cohort; Extracellular vesicles; Immune system; Medicine; Alzheimer's disease; Quantitative proteomics; Disease; Extracellular vesicle; Immunology; Microvesicles; Biology; Pathology; Bioinformatics; Cell biology; Biochemistry; microRNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009860569,0.0003930175,0.0003039145,0.0002265457,0.0001355382,0.00009673268,0.0003738821,0.0001666452,0.00005087457],"category_scores_gemma":[0.00009555086,0.0004485805,0.0001085855,0.0004160761,0.0001365098,0.00003708982,0.0004008139,0.000185437,0.00004700822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001055967,"about_ca_system_score_gemma":0.0001403746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003264029,"about_ca_topic_score_gemma":0.0001365109,"domain_scores_codex":[0.9970731,0.0004210476,0.0006516129,0.0009584469,0.0003339824,0.0005618124],"domain_scores_gemma":[0.9987323,0.00002539817,0.0001683255,0.0007678122,0.00007158637,0.0002345447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002814083,0.0007098569,0.4468161,0.000009949257,0.002352644,0.0001037483,0.0002177626,0.00007761601,0.5469868,0.0000110872,0.0001489974,0.002284008],"study_design_scores_gemma":[0.002532844,0.0001677121,0.6787838,0.00003206551,0.003278153,0.000003081343,0.000344349,0.002042135,0.3119772,0.00006282007,0.0002439039,0.0005319484],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9120542,0.08557186,0.0001404332,0.00009556933,0.0001004993,0.001926107,0.00004425802,0.00004984213,0.00001726243],"genre_scores_gemma":[0.9968945,0.000384438,0.001509901,0.00008252632,0.00007199883,0.0005031978,0.0004620952,0.00008066357,0.00001068567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2350096,"threshold_uncertainty_score":0.9997966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02058550337610688,"score_gpt":0.2756549757590886,"score_spread":0.2550694723829817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}