{"id":"W4362665150","doi":"10.1183/13993003.01625-2022","title":"Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension","year":2023,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; Cleveland Clinic; Pulmonary Hypertension Association; Stanford Maternal and Child Health Research Institute; University of Michigan; American Heart Association; Stanford Cardiovascular Institute, School of Medicine, Stanford University; U.S. Department of Veterans Affairs","keywords":"Angiogenesis; Kinase insert domain receptor; Wnt signaling pathway; Vascular endothelial growth factor; Pulmonary hypertension; Vascular remodelling in the embryo; Hypoxia (environmental); Cancer research; Biology; Cell biology; Medicine; Vascular endothelial growth factor A; Pathology; Signal transduction; Chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009407527,0.0003037482,0.0002561432,0.0004199056,0.0001372973,0.0002418066,0.000156684,0.000463721,0.004617237],"category_scores_gemma":[0.0001400462,0.0001584169,0.0002927461,0.0002146598,0.0003014573,0.0001557567,0.0002123483,0.0004904005,0.0005768434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001479919,"about_ca_system_score_gemma":0.0001149775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003654963,"about_ca_topic_score_gemma":0.0004411285,"domain_scores_codex":[0.9998542,0.0000203252,0.00002200388,0.00004174775,0.00003740107,0.00002425941],"domain_scores_gemma":[0.9996699,0.00002796016,0.0001707931,0.0000168747,0.00001705364,0.00009747381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003689126,0.00003027493,0.002224211,0.00008660732,0.00002511443,0.0007699464,0.00001583392,0.00003483968,0.9948556,0.0001097915,0.00009906897,0.001379772],"study_design_scores_gemma":[0.000136874,0.0009297197,0.2258202,0.00008597488,0.0003007381,0.02317331,0.0001987462,0.002696745,0.7370407,0.0005398748,0.009050589,0.00002655424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934763,0.001778435,0.002271898,0.0001569866,0.00004725282,0.00002103118,0.001121041,0.0001178745,0.001009194],"genre_scores_gemma":[0.9950278,0.001015366,0.0009177229,0.0000512731,0.00002037349,0.0000311066,0.0008979502,0.00002955718,0.002008792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004617237,"threshold_uncertainty_score":0.01544625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05555088052798164,"score_gpt":0.2695759506469357,"score_spread":0.2140250701189541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}