{"id":"W4362665274","doi":"10.3390/ctn7020011","title":"Genetic and Epigenetic Study of Monozygotic Twins Affected by Parkinson’s Disease","year":2023,"lang":"en","type":"article","venue":"Clinical and Translational Neuroscience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; Toronto Western Hospital; Occupational Cancer Research Centre; University of Toronto","funders":"National Health Commission of the People's Republic of China; National Natural Science Foundation of China; Fundamental Research Funds for the Central Universities; Consortium canadien en neurodégénérescence associée au vieillissement; Natural Science Foundation of Shanghai","keywords":"dNaM; Genetics; Epigenetics; Monozygotic twin; DNA methylation; Age of onset; Biology; Zygosity; Epigenomics; Twin study; Disease; Medicine; Heritability; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000384588,0.0003916497,0.0004319791,0.001316172,0.001074913,0.000290766,0.0002821037,0.0004007648,0.001012888],"category_scores_gemma":[0.001777259,0.0002615587,0.0003465269,0.0006776148,0.0003672323,0.0001227913,0.0005898252,0.0003017339,0.0001097308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004289635,"about_ca_system_score_gemma":0.0003853091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006900661,"about_ca_topic_score_gemma":0.005408842,"domain_scores_codex":[0.9995893,0.0000815623,0.00004662293,0.0001289549,0.0001017745,0.00005184188],"domain_scores_gemma":[0.9994698,0.00008188345,0.0001352157,0.00006262901,0.0001023572,0.0001480796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001200964,0.000236277,0.9207759,0.00005864691,0.0002424649,0.01359673,0.003378848,0.0001611157,0.05373761,0.000440408,0.0002185319,0.005952382],"study_design_scores_gemma":[0.0000314212,0.0004263882,0.9648004,0.00001442565,0.0001490102,0.0254899,0.0009370084,0.0006303755,0.006630529,0.0001399021,0.0007347023,0.00001597175],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996421,0.00003990307,0.00009831665,0.00001059689,0.000003766038,0.000009765499,0.00004868085,8.346452e-7,0.0001458514],"genre_scores_gemma":[0.9993495,0.00005205116,0.0002518618,0.00001475739,0.000003658659,0.000009575248,0.000101456,0.000002445513,0.0002146022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006900661,"threshold_uncertainty_score":0.01372099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03874942514071882,"score_gpt":0.3312429343093872,"score_spread":0.2924935091686683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}