{"id":"W4362669146","doi":"10.3390/biology12040556","title":"Tripeptide IRW Improves AMPK/eNOS Signaling Pathway via Activating ACE2 in the Aorta of High-Fat-Diet-Fed C57BL/6 Mice","year":2023,"lang":"en","type":"article","venue":"Biology","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Enos; AMPK; Endocrinology; Internal medicine; Signal transduction; Cell biology; Nitric oxide; Phosphorylation; Nitric oxide synthase; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005708133,0.0001791125,0.0004771664,0.0001794146,0.00006208741,0.000008032161,0.0002117435,0.000163026,0.00006232877],"category_scores_gemma":[0.0008032133,0.0001192078,0.0001309747,0.0004809611,0.0001262777,0.00006040454,0.00007186744,0.0002166375,0.00005891094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001925705,"about_ca_system_score_gemma":0.0001050283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004696536,"about_ca_topic_score_gemma":0.00004067297,"domain_scores_codex":[0.9984872,0.0002159332,0.0004311609,0.0003260356,0.0001362091,0.0004034597],"domain_scores_gemma":[0.9987523,0.0005567435,0.0001892222,0.0003426243,0.00006694209,0.00009215431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007862377,0.0001832776,0.006425354,0.0001181937,0.00006358734,0.00003771226,0.00113575,0.000004437297,0.9750598,0.001080941,0.0007372512,0.01436748],"study_design_scores_gemma":[0.01543834,0.003780263,0.3925229,0.0005059029,0.0004860042,0.00002755705,0.01558878,0.0008521451,0.521073,0.008299726,0.04026466,0.001160748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968475,0.0005799892,0.00004497472,0.0006149167,0.0003748741,0.0004314325,0.0000328926,0.00008072798,0.0009926877],"genre_scores_gemma":[0.9979606,0.0000576545,0.0002151282,0.0008194327,0.0004624952,0.00005834097,0.0001155286,0.00002224742,0.0002885461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4539868,"threshold_uncertainty_score":0.4861154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02473261451850984,"score_gpt":0.2912796069807639,"score_spread":0.2665469924622541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}