{"id":"W4362676476","doi":"10.1371/journal.pgen.1010709","title":"Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan","year":2023,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Invertebrate Immune Response Mechanisms","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fusion Oriented REsearch for disruptive Science and Technology; Japan Science and Technology Agency; Japan Society for the Promotion of Science; Yakult Bio-Science Foundation; Institute of Genetics; Japan Agency for Medical Research and Development","keywords":"Biology; Peptidoglycan; Drosophila melanogaster; Antimicrobial peptides; Microbiology; Midgut; Transcriptome; Cell biology; Gut flora; Ageing; Longevity; Defensin; Bacteria; Genetics; Immunology; Antimicrobial; Gene; Gene expression; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000156126,0.0001577291,0.0002691498,0.0001759901,0.0001099943,0.00001290386,0.0001286099,0.0002225193,0.000273645],"category_scores_gemma":[0.00009409578,0.000159309,0.00005038804,0.0001976554,0.0001695072,0.00002960723,0.0001391672,0.0001292259,0.0005957557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001330433,"about_ca_system_score_gemma":0.00004635138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001133381,"about_ca_topic_score_gemma":0.0000127805,"domain_scores_codex":[0.998961,0.0002128051,0.0002840904,0.0002094381,0.00004305206,0.0002896116],"domain_scores_gemma":[0.9993958,0.0001532869,0.0001079608,0.0002300366,0.00009057825,0.00002231076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000204546,0.00006751994,0.0003429647,0.00004105435,0.0001287055,0.000003917453,0.0004226623,8.059698e-7,0.9926419,0.00007775527,0.001002102,0.005066093],"study_design_scores_gemma":[0.001067958,0.0003744106,0.001874061,0.00004650272,0.00009715608,0.00003362177,0.000214021,0.00007699461,0.9929104,0.0008966501,0.002218428,0.0001898278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975346,0.0008640465,0.000008124332,0.0003482088,0.0005882268,0.0001980502,0.0002603048,0.00009454962,0.0001039275],"genre_scores_gemma":[0.9978721,0.000998321,0.0002076111,0.0001094884,0.00005305517,0.00002135816,0.0004793661,0.00003314211,0.0002256111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004876265,"threshold_uncertainty_score":0.7657433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03908187138853449,"score_gpt":0.2373467455109381,"score_spread":0.1982648741224036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}