{"id":"W4362676476","doi":"10.1371/journal.pgen.1010709","title":"Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan","year":2023,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Invertebrate Immune Response Mechanisms","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fusion Oriented REsearch for disruptive Science and Technology; Japan Science and Technology Agency; Japan Society for the Promotion of Science; Yakult Bio-Science Foundation; Institute of Genetics; Japan Agency for Medical Research and Development","keywords":"Biology; Peptidoglycan; Drosophila melanogaster; Antimicrobial peptides; Microbiology; Midgut; Transcriptome; Cell biology; Gut flora; Ageing; Longevity; Defensin; Bacteria; Genetics; Immunology; Antimicrobial; Gene; Gene expression; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004991263,0.0001832306,0.0001341145,0.0004185564,0.000116129,0.000252987,0.000088695,0.0001686362,0.0007058471],"category_scores_gemma":[0.0000777954,0.0001201887,0.0001384534,0.0001444197,0.0001211163,0.0001418212,0.0002010806,0.0002473666,0.000266942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003162207,"about_ca_system_score_gemma":0.00007510075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008790666,"about_ca_topic_score_gemma":0.00170147,"domain_scores_codex":[0.9999353,0.000007012402,0.000005941186,0.00002377547,0.00001520026,0.0000127481],"domain_scores_gemma":[0.9998951,0.000009447933,0.000042738,0.000007233453,0.00001436611,0.00003096859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006310881,0.000004202732,0.002059113,0.00001788088,0.000002526713,0.00002045446,0.00002215433,0.0000303289,0.996155,0.00002703223,0.00003031233,0.001567903],"study_design_scores_gemma":[0.00001279487,0.0002554957,0.6115184,0.00002714518,0.00002901468,0.0003884959,0.000191724,0.001191768,0.3817821,0.0001116656,0.004472138,0.00001926861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943662,0.001803708,0.0008824764,0.00002637135,0.000005542093,0.000009566294,0.001111602,0.00004266034,0.001752008],"genre_scores_gemma":[0.9954817,0.0006352402,0.001092006,0.00005521057,0.000004396038,0.00002262145,0.001122002,0.00002338637,0.001563348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008790666,"threshold_uncertainty_score":0.002361238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03908187138853449,"score_gpt":0.2373467455109381,"score_spread":0.1982648741224036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}