{"id":"W4362677698","doi":"10.1101/2023.04.05.535802","title":"Metformin regulates bone marrow stromal cells to accelerate bone healing in diabetic mice","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University","keywords":"Metformin; Medicine; Bone healing; Endochondral ossification; Endocrinology; Internal medicine; Diabetes mellitus; Type 2 diabetes; Bone marrow; Osteoporosis; Stromal cell; Cartilage; Surgery; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003714391,0.0006117947,0.0004993432,0.001011762,0.0003060592,0.0004326462,0.0003841069,0.0007031273,0.002462789],"category_scores_gemma":[0.0001686964,0.0003212564,0.0007320407,0.0004156745,0.0003984407,0.0002959277,0.0003310279,0.001911549,0.0006366437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003436309,"about_ca_system_score_gemma":0.0003994586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009112165,"about_ca_topic_score_gemma":0.001478973,"domain_scores_codex":[0.9995517,0.00006033746,0.00006086512,0.00008391515,0.0001389516,0.0001041918],"domain_scores_gemma":[0.9996839,0.00001944952,0.00009807388,0.00002867542,0.00003481868,0.0001351331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001310107,0.0004217559,0.0004320997,0.00011408,0.00001787882,0.00009650866,0.00003589336,0.0001125855,0.9943905,0.0002017434,0.0001889959,0.002677829],"study_design_scores_gemma":[0.000487466,0.003436477,0.009175897,0.0000485058,0.00008740351,0.0002851785,0.0001574761,0.001948272,0.9761304,0.0002266512,0.00798726,0.00002902165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852228,0.003048094,0.004829127,0.0004638073,0.0003468443,0.0001731154,0.002455796,0.000286716,0.00317374],"genre_scores_gemma":[0.9811285,0.002581097,0.005075719,0.0004365965,0.00007144827,0.0004977639,0.002037919,0.00008635024,0.008084673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002462789,"threshold_uncertainty_score":0.008238792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01471822049152759,"score_gpt":0.2276890466392849,"score_spread":0.2129708261477573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}