{"id":"W4362691876","doi":"10.1371/journal.pone.0284026","title":"Comprehensive proteomic analysis of autophagosomes derived from Leishmania-infected macrophages","year":2023,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Genome British Columbia","keywords":"Autophagy; Leishmania donovani; Proteome; Biology; Leishmania; Cell biology; Intracellular parasite; Amastigote; Intracellular; Autophagosome; Phagosome; Cell culture; Biochemistry; Leishmaniasis; Immunology; Visceral leishmaniasis; Apoptosis; Parasite hosting; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174376,0.0004341442,0.0003488188,0.0007053975,0.0002353437,0.0002018564,0.0001548031,0.0001969329,0.0003335805],"category_scores_gemma":[0.0001304766,0.0001370455,0.0002760876,0.0004546077,0.0001670039,0.0001541936,0.0002123208,0.0002390529,0.0002773254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001510912,"about_ca_system_score_gemma":0.0002063326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003272388,"about_ca_topic_score_gemma":0.0004897621,"domain_scores_codex":[0.9999168,0.00001066262,0.000007872743,0.00002099776,0.00002793039,0.0000157356],"domain_scores_gemma":[0.9999263,0.00001292459,0.00001534185,0.0000058287,0.00002617729,0.00001336161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008476224,0.000006827542,0.0004345536,0.00007437988,0.00001010455,0.0000700509,0.00001886663,0.00001670332,0.9986293,0.00001808692,0.00002583358,0.0006105293],"study_design_scores_gemma":[0.00002770952,0.0004071922,0.09493713,0.00005328491,0.0001628804,0.001995651,0.0003099155,0.001250228,0.8932025,0.0001467856,0.007477522,0.00002910592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986647,0.005268112,0.003464424,0.00008177616,0.00003905165,0.00007046555,0.003112374,0.00005466014,0.001262159],"genre_scores_gemma":[0.9651562,0.006914124,0.01563575,0.0002588055,0.00004989688,0.0002082656,0.008863226,0.00006407876,0.002849529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007053975,"threshold_uncertainty_score":0.001115918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0459505858626085,"score_gpt":0.2744397141477717,"score_spread":0.2284891282851632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}