{"id":"W4362694641","doi":"10.1016/j.stem.2023.03.003","title":"Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors","year":2023,"lang":"en","type":"letter","venue":"Cell stem cell","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; Generalitat de Catalunya; Centres de Recerca de Catalunya","keywords":"Biology; Enteroendocrine cell; Progenitor cell; Somatostatin; Pancreas; Endocrine system; Lineage (genetic); Ductal cells; Cell lineage; Stem cell; Cell biology; Pancreatic duct; Progenitor; Internal medicine; Endocrinology; Cellular differentiation; Hormone; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004267319,0.0006492872,0.001388256,0.0006904704,0.003053028,0.003819386,0.001373156,0.04214893,0.00460453],"category_scores_gemma":[0.0285174,0.0006162411,0.001117776,0.0007148315,0.003626419,0.003449033,0.00188399,0.04686815,0.005929768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00343789,"about_ca_system_score_gemma":0.002801798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001911992,"about_ca_topic_score_gemma":0.002886645,"domain_scores_codex":[0.997475,0.0007964349,0.0003790483,0.0003505846,0.0006816951,0.0003172188],"domain_scores_gemma":[0.98684,0.008399806,0.0007619659,0.0005170597,0.001775178,0.001705987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001147818,0.00004156265,0.001244197,0.00008639661,0.00003631297,0.005189908,0.0001860023,0.0000587607,0.0004606332,0.003033872,0.9693512,0.0201963],"study_design_scores_gemma":[0.0002093766,0.00009427081,0.001546079,0.000427374,0.0001189222,0.008663834,0.0007879487,0.000535831,0.0007575267,0.02981912,0.9569568,0.00008295255],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0005325067,0.001833443,0.000133716,0.9723836,0.02362533,0.000005458716,0.000029585,0.00001810258,0.001438364],"genre_scores_gemma":[0.006448079,0.001730776,0.0002677634,0.9017428,0.08664816,0.00002154314,0.0000326048,0.00002649877,0.003081678],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04214893,"threshold_uncertainty_score":0.02494377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0399890739963133,"score_gpt":0.2352778292517217,"score_spread":0.1952887552554085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}