{"id":"W4362694641","doi":"10.1016/j.stem.2023.03.003","title":"Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors","year":2023,"lang":"en","type":"letter","venue":"Cell stem cell","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; Generalitat de Catalunya; Centres de Recerca de Catalunya","keywords":"Biology; Enteroendocrine cell; Progenitor cell; Somatostatin; Pancreas; Endocrine system; Lineage (genetic); Ductal cells; Cell lineage; Stem cell; Cell biology; Pancreatic duct; Progenitor; Internal medicine; Endocrinology; Cellular differentiation; Hormone; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001727058,0.0009855768,0.001443303,0.0003852392,0.0002496741,0.0003366982,0.0004541535,0.0009411384,0.0003290201],"category_scores_gemma":[0.00007676865,0.0008806765,0.000531265,0.0004261735,0.0002057472,0.0001641778,0.0002185449,0.001889038,0.002142115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003126528,"about_ca_system_score_gemma":0.0002546545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002380413,"about_ca_topic_score_gemma":0.000001315555,"domain_scores_codex":[0.9950029,0.0003360721,0.0008397804,0.001492999,0.001252695,0.001075591],"domain_scores_gemma":[0.9957081,0.001264825,0.001110918,0.001301846,0.0002405202,0.0003737913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001057029,0.0002021366,0.00693526,0.003127382,0.00014636,0.0025948,0.0007170431,0.00002228952,0.1883136,7.866868e-8,0.7976668,0.0001685639],"study_design_scores_gemma":[0.002804088,0.0005101389,0.002735441,0.009385513,0.002940953,0.00005357395,0.002715611,0.0006682553,0.818529,0.00001173748,0.157763,0.001882689],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.9264225,0.003486553,0.0001667555,0.06040068,0.005123512,0.001751696,0.0001670529,0.0007535694,0.001727712],"genre_scores_gemma":[0.3466078,0.0009369323,0.001269257,0.5920516,0.009076719,0.0003949063,0.001301913,0.0009339461,0.04742686],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6399038,"threshold_uncertainty_score":0.9993644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0399890739963133,"score_gpt":0.2352778292517217,"score_spread":0.1952887552554085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}