{"id":"W4362700442","doi":"10.1038/s41419-022-05484-3","title":"Autophagy deficiency exacerbates iron overload induced reactive oxygen species production and apoptotic cell death in skeletal muscle cells","year":2023,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Canadian Institutes of Health Research; York University; International Development Research Centre; Government of Canada","keywords":"Autophagy; Reactive oxygen species; Cell biology; Apoptosis; Programmed cell death; Skeletal muscle; Oxygen; Mitochondrion; Myocyte; Biology; Chemistry; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002207284,0.0003570922,0.00078936,0.0003041148,0.000209129,0.000244885,0.0001675096,0.0004321243,0.001328877],"category_scores_gemma":[0.00009253674,0.0001872894,0.0003872058,0.0001412855,0.0001975269,0.0002036884,0.0002432781,0.0006470731,0.0003380273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000170278,"about_ca_system_score_gemma":0.000239739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005550642,"about_ca_topic_score_gemma":0.001321035,"domain_scores_codex":[0.9998209,0.00003235358,0.00003171536,0.00003261563,0.00003751953,0.00004497057],"domain_scores_gemma":[0.9998976,0.00001109967,0.00002593612,0.00001146061,0.00001655897,0.00003731472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000375757,0.00008999847,0.0002899974,0.00007793391,0.000009323568,0.0001541916,0.00003110981,0.00002911925,0.9980153,0.00002681248,0.00006530852,0.0008352426],"study_design_scores_gemma":[0.0001592217,0.004129138,0.02765312,0.00007665111,0.0001054735,0.001229137,0.0002520354,0.002010497,0.9593854,0.0001530289,0.00482867,0.00001767863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965631,0.001443373,0.0007911264,0.0001057698,0.00003968036,0.00003092845,0.0001536396,0.00006264293,0.0008096508],"genre_scores_gemma":[0.9942716,0.001142763,0.001008564,0.0001277603,0.00001980203,0.00007557485,0.0004360932,0.00001474567,0.00290319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001328877,"threshold_uncertainty_score":0.004445553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01858606746596604,"score_gpt":0.2494177468013054,"score_spread":0.2308316793353394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}