{"id":"W4362703505","doi":"10.1016/j.ijantimicag.2023.106807","title":"Antimalarials and amphotericin B interact synergistically and are new options to treat cryptococcosis","year":2023,"lang":"en","type":"article","venue":"International Journal of Antimicrobial Agents","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Ministério da Saúde; Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Universidade Federal de Minas Gerais; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Cryptococcus neoformans; Cryptococcosis; Cryptococcus gattii; Amphotericin B; Microbiology; Biology; Cryptococcus; Fluconazole; Itraconazole; Ergosterol; Antifungal; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002790372,0.0002073198,0.0003863132,0.0004338721,0.0002020674,0.0005447896,0.0001660548,0.0003723138,0.001970533],"category_scores_gemma":[0.0002686234,0.00007976226,0.0002702709,0.0003192216,0.0002401773,0.0004653439,0.0003704175,0.0007887644,0.000454078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001524081,"about_ca_system_score_gemma":0.0003024761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001733275,"about_ca_topic_score_gemma":0.0008340553,"domain_scores_codex":[0.9998199,0.00005198986,0.0000164704,0.0000161305,0.00006292813,0.00003261069],"domain_scores_gemma":[0.9998579,0.00003715388,0.00004602809,0.000008346801,0.00002203231,0.00002857527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002972217,0.0007474466,0.005455575,0.001439874,0.0002357497,0.001859908,0.0001028611,0.000541322,0.0857824,0.004178898,0.009925048,0.8867587],"study_design_scores_gemma":[0.002812843,0.01472593,0.0759581,0.001710707,0.001140257,0.03450299,0.0007893404,0.003217985,0.07764461,0.01118791,0.7761941,0.0001152126],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2399234,0.7131663,0.003886411,0.01437833,0.001496954,0.00008134708,0.0001933815,0.0001660348,0.02670785],"genre_scores_gemma":[0.7803752,0.2025141,0.004787535,0.003277439,0.001602614,0.00005369545,0.0002349771,0.00001240628,0.007142095],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001970533,"threshold_uncertainty_score":0.006592095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0336592069919572,"score_gpt":0.3380806009197512,"score_spread":0.304421393927794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}