{"id":"W4362717907","doi":"10.1038/s41467-023-37377-0","title":"Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; National Human Genome Research Institute; University of Arizona; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Cincinnati Children's Hospital Medical Center; University of Arizona Cancer Center; National Institute of Environmental Health Sciences; University of Cincinnati; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Keratinocyte; Biology; Carcinogenesis; Transcriptome; Epithelium; Cell cycle; Transcription factor; Cancer research; Cell; Cancer; Cell culture; Gene; Gene expression; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000100036,0.0001167678,0.0001752772,0.0003054817,0.000207296,0.0003907849,0.00006920507,0.0001862606,0.0009335566],"category_scores_gemma":[0.00015455,0.00009556652,0.0001839567,0.000292113,0.0001623336,0.0001728291,0.0001681478,0.0001989546,0.0002964247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001536125,"about_ca_system_score_gemma":0.0001475067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006084971,"about_ca_topic_score_gemma":0.0014309,"domain_scores_codex":[0.9999377,0.000004349287,0.000003250434,0.00002506975,0.00001499844,0.00001463726],"domain_scores_gemma":[0.9999259,0.00001729793,0.00001593414,0.00001206991,0.00001615504,0.00001258114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005333945,0.000003489102,0.004027924,0.00003860285,0.000004806735,0.00002294215,0.00005561064,0.00005761509,0.9935061,0.00004266663,0.00003832711,0.002148509],"study_design_scores_gemma":[0.000006132193,0.0002051522,0.3931331,0.00004191401,0.00007103554,0.0006684952,0.0007724517,0.00359993,0.5940719,0.0004749371,0.006935381,0.00001968307],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905136,0.0009239321,0.005011272,0.00004678265,0.00001561576,0.00001380191,0.00260785,0.00008795905,0.0007792069],"genre_scores_gemma":[0.9889219,0.0008730962,0.005502567,0.00004884898,0.000005439832,0.00003068534,0.003049728,0.00004382195,0.001523988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009335566,"threshold_uncertainty_score":0.003123045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06629153214827944,"score_gpt":0.3990792863099613,"score_spread":0.3327877541616819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}