{"id":"W4362731336","doi":"10.20944/preprints202304.0108.v1","title":"Towards a Biological Definition of Parkinson’s Disease","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Toronto Western Hospital; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Parkinson Canada; Bundesministerium für Bildung und Forschung; Damp Stiftung; Deutsche Forschungsgemeinschaft; Parkinsonfonden; Weston Brain Institute; Fondation Brain Canada; Ontario Brain Institute; Michael J. Fox Foundation for Parkinson's Research","keywords":"Parkinsonism; Neurodegeneration; Disease; Parkinson's disease; Neuroscience; Lewy body; Medicine; Dementia with Lewy bodies; Pathology; REM sleep behavior disorder; Psychology; Dementia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01031043,0.002075755,0.002204143,0.006567603,0.001807473,0.00520712,0.004108335,0.004968062,0.001574188],"category_scores_gemma":[0.00797752,0.0004862575,0.001847185,0.002420051,0.01191394,0.007723856,0.004899253,0.0104228,0.002011137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004764724,"about_ca_system_score_gemma":0.005487997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003108664,"about_ca_topic_score_gemma":0.001797412,"domain_scores_codex":[0.9938961,0.002450086,0.001269346,0.0009109552,0.001156811,0.0003167699],"domain_scores_gemma":[0.9922706,0.002218352,0.0009903593,0.0004427708,0.003380889,0.0006970231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001390539,0.0001574879,0.005410014,0.001478306,0.0001079277,0.001061736,0.002713267,0.001093705,0.005154713,0.8667551,0.03614748,0.07978112],"study_design_scores_gemma":[0.0000566809,0.0003389673,0.007597999,0.001933451,0.0001056256,0.005172745,0.001992967,0.002590516,0.000997572,0.4215384,0.5575396,0.0001352844],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.0281408,0.3256545,0.2702717,0.2503836,0.0305638,0.0005925828,0.002007596,0.0005904243,0.09179504],"genre_scores_gemma":[0.3079371,0.1577394,0.3921546,0.07933447,0.0372634,0.002061177,0.006449535,0.0005331374,0.0165273],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01031043,"threshold_uncertainty_score":0.0545274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2564967264626223,"score_gpt":0.3710736754361513,"score_spread":0.1145769489735289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}