{"id":"W4362731336","doi":"10.20944/preprints202304.0108.v1","title":"Towards a Biological Definition of Parkinson’s Disease","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Toronto Western Hospital; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Parkinson Canada; Bundesministerium für Bildung und Forschung; Damp Stiftung; Deutsche Forschungsgemeinschaft; Parkinsonfonden; Weston Brain Institute; Fondation Brain Canada; Ontario Brain Institute; Michael J. Fox Foundation for Parkinson's Research","keywords":"Parkinsonism; Neurodegeneration; Disease; Parkinson's disease; Neuroscience; Lewy body; Medicine; Dementia with Lewy bodies; Pathology; REM sleep behavior disorder; Psychology; Dementia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003900575,0.0004631801,0.0008272195,0.0002563954,0.00006327585,0.00000992467,0.0003029792,0.0004006047,0.001054034],"category_scores_gemma":[0.0005709336,0.000398793,0.0006274307,0.0001828682,0.0001274659,0.00003601591,0.001349526,0.000526803,0.001954022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002091452,"about_ca_system_score_gemma":0.0005236696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002039757,"about_ca_topic_score_gemma":0.00000441518,"domain_scores_codex":[0.9970793,0.0001423054,0.0006045334,0.001217154,0.0005430546,0.0004136642],"domain_scores_gemma":[0.9974769,0.00005851792,0.0003510326,0.001341953,0.0001878472,0.0005837518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008828977,0.001151347,0.9922947,0.0006629959,0.0005785906,0.0005764121,0.0001202142,0.00001354233,0.001537943,0.001368321,0.00007240757,0.0007405931],"study_design_scores_gemma":[0.001144937,0.00008030832,0.9542575,0.0006224567,0.0005814451,0.000007727419,0.00003159029,0.00005525442,0.004696247,0.03423604,0.003989802,0.0002966427],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916046,0.000432314,0.0001478342,0.0006289037,0.0005978093,0.001115153,0.0005584119,0.0004095614,0.004505364],"genre_scores_gemma":[0.9952537,0.001438456,0.0009349599,0.0001644804,0.0001791242,0.0006196697,0.0009152867,0.00006943889,0.0004248824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03803718,"threshold_uncertainty_score":0.9998592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2564967264626223,"score_gpt":0.3710736754361513,"score_spread":0.1145769489735289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}