{"id":"W4362735831","doi":"10.1002/cpt.2903","title":"Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for <i>CYP2D6</i>, <i>CYP2C19</i>, <i>CYP2B6</i>, <i>SLC6A4</i>, and <i>HTR2A</i> Genotypes and Serotonin Reuptake Inhibitor Antidepressants","year":2023,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":403,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health; Alberta Children's Hospital; University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institutes of Health; Patient-Centered Outcomes Research Institute","keywords":"CYP2C19; Pharmacogenetics; Serotonin reuptake inhibitor; Medicine; CYP2B6; CYP2D6; Guideline; Internal medicine; Genotype; Serotonin; CYP3A4; Biology; Genetics; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01661277,0.000892085,0.001677453,0.002293568,0.001074679,0.003255442,0.004179109,0.008797057,0.01778535],"category_scores_gemma":[0.05332901,0.000783512,0.003559144,0.002437185,0.001216049,0.001840743,0.002621705,0.008102245,0.009264271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003292792,"about_ca_system_score_gemma":0.01931458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02220118,"about_ca_topic_score_gemma":0.03128536,"domain_scores_codex":[0.9750597,0.009213463,0.00540249,0.001127296,0.007992034,0.001204962],"domain_scores_gemma":[0.9531451,0.01487858,0.004371776,0.001948484,0.02320146,0.002454518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000141661,0.0002078589,0.001642332,0.001254457,0.00008685019,0.0005092226,0.0002877028,0.0005919955,0.0007492058,0.008903202,0.8382323,0.1473931],"study_design_scores_gemma":[0.0003450899,0.0001358418,0.003971928,0.004230154,0.0002026932,0.000981889,0.0001557398,0.0007562956,0.0007204819,0.005766828,0.9826699,0.0000630586],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"methods","genre_scores_codex":[0.007226702,0.04693409,0.1123848,0.3577135,0.01688759,0.009865277,0.03092936,0.007087969,0.4109707],"genre_scores_gemma":[0.06044274,0.0621859,0.2061799,0.4457034,0.009284412,0.01713522,0.07320195,0.002445519,0.123421],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.02220118,"threshold_uncertainty_score":0.08785778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.260799143689104,"score_gpt":0.5708299925254577,"score_spread":0.3100308488363537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}