{"id":"W4363646040","doi":"10.1083/jcb.202207130","title":"Autolysosomal exocytosis of lipids protect neurons from ferroptosis","year":2023,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Neuroscience and Mental Health Institute, University of Alberta; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; NIH Office of the Director; National Human Genome Research Institute; National Institute on Aging; Canada Research Chairs; National Institutes of Health; NHLBI Division of Intramural Research; Texas Children's Hospital; University Hospital Foundation; Canadian Institutes of Health Research; Faculty of Medicine and Dentistry, University of Alberta; BrightFocus Foundation; Alzheimer Society; Heart and Stroke Foundation of Canada; University of Alberta; National Institute of Child Health and Human Development; Alfred P. Sloan Foundation; Howard Hughes Medical Institute","keywords":"Exocytosis; Cell biology; Oxidative stress; Lipid peroxidation; Membrane lipids; Protein aggregation; Programmed cell death; Lipidome; Chemistry; Biology; Biochemistry; Lipid metabolism; Apoptosis; Secretion; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001656695,0.0002235058,0.0002784671,0.0001095326,0.0001274161,0.0002731021,0.0001975686,0.00029762,0.0007454888],"category_scores_gemma":[0.0001500742,0.00008506123,0.0001998945,0.00004525859,0.0002084182,0.0003097606,0.0002376928,0.0004061233,0.0002850493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001452531,"about_ca_system_score_gemma":0.0001755764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001562531,"about_ca_topic_score_gemma":0.000268466,"domain_scores_codex":[0.9999317,0.00001023921,0.0000099942,0.00001437342,0.00001729882,0.0000163736],"domain_scores_gemma":[0.9998719,0.00002714285,0.00003184391,0.00002902459,0.00002036817,0.00001974479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007782719,0.000008587947,0.0001535366,0.00002766925,0.000004740612,0.0000526071,0.00001464251,0.00002936528,0.9986571,0.00008217744,0.0000235004,0.0008682185],"study_design_scores_gemma":[0.000007298132,0.00008594205,0.002551649,0.000007237858,0.000006374845,0.0002632,0.0000197647,0.0002693067,0.9961435,0.0001085068,0.000534787,0.00000236741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932181,0.001484328,0.004121215,0.0001357156,0.00003518609,0.00001804262,0.0001695034,0.00008829752,0.000729565],"genre_scores_gemma":[0.9942221,0.0009856314,0.002828558,0.00006920562,0.000008590379,0.00002505795,0.0002034062,0.00003537598,0.001622103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007454888,"threshold_uncertainty_score":0.002493858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01933959954146269,"score_gpt":0.2740981064942167,"score_spread":0.254758506952754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}