{"id":"W4363647866","doi":"10.3390/biology12040572","title":"Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin","year":2023,"lang":"en","type":"article","venue":"Biology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba; Research Manitoba","funders":"Purdue University; Heart and Stroke Foundation of Canada","keywords":"Biology; Adenylyl cyclase; Forskolin; ADCY9; Gene isoform; ADCY10; Biochemistry; Cell biology; Enzyme; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001176211,0.00006283388,0.0001723086,0.0001298414,0.00001994083,0.000001928307,0.00003259354,0.00006307447,0.00003572812],"category_scores_gemma":[0.0001751684,0.00004283494,0.000027284,0.0001998575,0.00003352609,0.00003311426,0.00002137493,0.0000693773,0.00005394014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009052617,"about_ca_system_score_gemma":0.00002283947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002924946,"about_ca_topic_score_gemma":0.00001002575,"domain_scores_codex":[0.9995437,0.00002447912,0.0001383928,0.0001102814,0.00004056468,0.0001425772],"domain_scores_gemma":[0.9995791,0.0001575238,0.00007684347,0.0001125473,0.00004077627,0.00003318888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003900482,0.00002719577,0.07125831,0.00008045743,0.0000396461,0.00002343946,0.0002046853,8.337543e-7,0.9183177,0.0001305094,0.0001423378,0.009384851],"study_design_scores_gemma":[0.00291619,0.001972843,0.4700131,0.0004390132,0.0001034184,0.0001512697,0.0003574181,0.0006906352,0.5105093,0.0002429569,0.01239744,0.000206422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984403,0.0000155067,0.0002614538,0.0004348748,0.0001338969,0.0001475476,0.00001004397,0.0000749454,0.0004814356],"genre_scores_gemma":[0.9985343,0.00005323115,0.0002650416,0.0001448529,0.0001587988,0.00001226343,0.0001811091,0.00001134856,0.0006390465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4078084,"threshold_uncertainty_score":0.1746758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01932939628605661,"score_gpt":0.296628732689172,"score_spread":0.2772993364031154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}