{"id":"W4364302116","doi":"10.1039/d3sc01072d","title":"Synthesis of spirooxindoles<i>via</i>formal acetylene insertion into a common palladacycle intermediate","year":2023,"lang":"en","type":"article","venue":"Chemical Science","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Kennarshore; University of Toronto; Universities Space Research Association; Natural Sciences and Engineering Research Council of Canada; University of Denver","keywords":"Acetylene; Chemistry; Alkene; Combinatorial chemistry; Aryl; Catalysis; Sequence (biology); Palladium; Surface modification; Stereochemistry; Organic chemistry; Alkyl","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001147788,0.0002420334,0.0001595313,0.0001467752,0.0001384079,0.0002733832,0.0002321231,0.000168312,0.001504649],"category_scores_gemma":[0.0001039202,0.000135895,0.0001605651,0.0001287741,0.0001424029,0.0002100637,0.000281671,0.0003636582,0.000738917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002224598,"about_ca_system_score_gemma":0.0003046528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002634658,"about_ca_topic_score_gemma":0.0005173514,"domain_scores_codex":[0.9999232,0.000008889858,0.000008560966,0.00002018116,0.00001461545,0.00002449393],"domain_scores_gemma":[0.9999623,0.000003923307,0.00001067897,0.000006734611,0.000006138943,0.00001023153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006351147,0.00004157128,0.0002275913,0.0001320926,0.00001239994,0.0002195489,0.00007898388,0.0003428939,0.9833681,0.004769763,0.0002251458,0.0105183],"study_design_scores_gemma":[0.00002586465,0.0005258282,0.0009788655,0.00001096228,0.00001558713,0.0003488266,0.00002415243,0.0005653994,0.9786264,0.0004289115,0.01843425,0.00001483642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9217497,0.001577523,0.04170535,0.0001804588,0.0001408278,0.0002444652,0.0007218351,0.0004934501,0.03318632],"genre_scores_gemma":[0.9813669,0.0008265486,0.01317106,0.00007209707,0.00001319003,0.00005625264,0.0002919575,0.00002437146,0.004177524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001504649,"threshold_uncertainty_score":0.005033612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01818028648962718,"score_gpt":0.290723577019683,"score_spread":0.2725432905300558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}