{"id":"W4364321089","doi":"10.7150/jca.79552","title":"Inhibition of PANX1 Channels Reduces the Malignant Properties of Human High-Risk Neuroblastoma","year":2023,"lang":"en","type":"article","venue":"Journal of Cancer","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Cancer Research Society; University of Ottawa","keywords":"Carbenoxolone; Neuroblastoma; Cancer research; Pannexin; Neural crest; Medicine; Cell growth; Internal medicine; Oncology; Biology; Cell biology; Intracellular; Cell culture; Gap junction; Embryo; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002388398,0.00008746581,0.0002843046,0.0001999036,0.00006134524,0.000008850829,0.00008153123,0.00002814564,0.00005004809],"category_scores_gemma":[0.00007648516,0.0000447069,0.0001284792,0.0002894494,0.0001297188,0.00008733221,0.00003627812,0.0001923847,0.000004722479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000374827,"about_ca_system_score_gemma":0.0001566197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001461644,"about_ca_topic_score_gemma":0.00001851852,"domain_scores_codex":[0.9987245,0.00008609185,0.0004002243,0.00008245534,0.000536439,0.0001702487],"domain_scores_gemma":[0.9989793,0.00003467828,0.000459686,0.0001240872,0.0003216063,0.00008062075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007266699,0.0001607825,0.001941742,0.000146962,0.0002375979,0.0001566457,0.000518552,0.0001204262,0.9905805,0.00001862539,0.001616431,0.003775086],"study_design_scores_gemma":[0.001403326,0.002089787,0.0347185,0.0008368168,0.0001260067,0.00005403341,0.00019208,0.00002307078,0.9602631,0.0001329387,0.0001242887,0.00003604275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975074,0.000520381,9.232531e-7,0.001519005,0.0001919739,0.0001843604,0.00001376344,0.000008357294,0.00005384702],"genre_scores_gemma":[0.9980958,0.001152962,0.000007205862,0.00003920661,0.0002308801,0.00001130099,8.129028e-7,0.00001581035,0.0004459873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03277676,"threshold_uncertainty_score":0.1823094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03994671715908308,"score_gpt":0.3189622345544368,"score_spread":0.2790155173953537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}