{"id":"W4364352000","doi":"10.2174/1386207326666230406124524","title":"HDL-Chitosan Nanoparticles for siRNA Delivery as an SR-B1 ReceptorTargeted System","year":2023,"lang":"en","type":"article","venue":"Combinatorial Chemistry & High Throughput Screening","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Anadolu Üniversitesi","keywords":"Chitosan; Transfection; Cytotoxicity; Chemistry; Receptor; Nanoparticle; Zeta potential; Oncogene; Biophysics; Cell culture; Cell; Molecular biology; Biochemistry; Nanotechnology; Materials science; In vitro; Biology; Cell cycle; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003234309,0.0004215422,0.0004017976,0.00004351686,0.0004192349,0.000124755,0.0006241702,0.0004323817,0.00003586824],"category_scores_gemma":[0.0001831804,0.0004568099,0.0002495502,0.0002941285,0.0001199183,0.00003906336,0.0002804615,0.0001927486,0.0000478735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003883605,"about_ca_system_score_gemma":0.0001406467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001381385,"about_ca_topic_score_gemma":0.00000599376,"domain_scores_codex":[0.9974012,0.00008050605,0.0005154438,0.0009422707,0.0003385386,0.0007220374],"domain_scores_gemma":[0.9984784,0.00005540072,0.0002106429,0.000760312,0.000229865,0.0002654211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005813009,0.00007517814,0.0002841326,0.0001285819,0.0001558799,0.0000172135,0.0000703729,0.0001483714,0.9908426,0.0005568266,0.005946361,0.001193213],"study_design_scores_gemma":[0.001812318,0.0005900231,0.000178062,0.0001045578,0.00007074722,0.00001677255,0.0007515497,0.0003841852,0.9847173,0.0004965928,0.01030849,0.0005693648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957169,0.0002814224,0.0003954388,0.0001057959,0.002006387,0.0003528599,0.00009221079,0.0002937861,0.000755233],"genre_scores_gemma":[0.9939606,0.0001039931,0.0006506637,0.00008149941,0.002878508,0.0001397407,0.00155901,0.00009060004,0.0005353584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006125233,"threshold_uncertainty_score":0.9997883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01788973028324372,"score_gpt":0.265122050115492,"score_spread":0.2472323198322483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}