{"id":"W4364352746","doi":"10.1128/msphere.00095-23","title":"Construction of Candida albicans Strains with ATP-Analog-Sensitive Protein Kinase A and Hog1","year":2023,"lang":"en","type":"article","venue":"mSphere","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Government of Canada; Canadian Institute for Advanced Research","keywords":"Candida albicans; Virulence; Microbiology; Yeast; Osmotic shock; Biology; Pathogen; Corpus albicans; Fungus; Fungal pathogen; Genetics; Gene; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000958864,0.00009025489,0.0002257988,0.00002653014,0.00004721312,0.000005735126,0.00001953199,0.00005386377,0.0001282202],"category_scores_gemma":[0.00005756824,0.00006711977,0.00003495577,0.0002422299,0.0002945984,0.00003640538,0.00001287689,0.000104147,0.000008646836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000279338,"about_ca_system_score_gemma":0.0001306168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004409907,"about_ca_topic_score_gemma":0.002178505,"domain_scores_codex":[0.9993286,0.00001918938,0.0001302575,0.0002003395,0.0001697785,0.0001518596],"domain_scores_gemma":[0.9995778,0.00002177696,0.00005288361,0.0001636903,0.00009972656,0.00008416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002423164,0.0002096674,0.619323,0.001266532,0.0004538395,0.001005177,0.003501597,0.000009462584,0.2851444,0.00276683,0.001012696,0.08288363],"study_design_scores_gemma":[0.001915641,0.0009455566,0.9617038,0.0005234799,0.0001505356,0.00006439603,0.01203182,0.0001503107,0.02111406,0.0001890404,0.001021349,0.0001900583],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935043,0.0000419658,0.0001055068,0.0004511357,0.00001358863,0.0003635871,0.0000416909,0.00004556055,0.00543269],"genre_scores_gemma":[0.9978027,0.00002679923,0.0006856335,0.00004330264,0.00002668027,0.000009156668,0.00001509155,0.0000104393,0.001380184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3423808,"threshold_uncertainty_score":0.2737065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01274080281792251,"score_gpt":0.2500727653035436,"score_spread":0.2373319624856211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}