{"id":"W4364352746","doi":"10.1128/msphere.00095-23","title":"Construction of Candida albicans Strains with ATP-Analog-Sensitive Protein Kinase A and Hog1","year":2023,"lang":"en","type":"article","venue":"mSphere","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Government of Canada; Canadian Institute for Advanced Research","keywords":"Candida albicans; Virulence; Microbiology; Yeast; Osmotic shock; Biology; Pathogen; Corpus albicans; Fungus; Fungal pathogen; Genetics; Gene; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000694504,0.0005884904,0.0003629262,0.001028005,0.0004960695,0.000614839,0.001609777,0.0006487639,0.001416003],"category_scores_gemma":[0.0005139974,0.0004536359,0.00057265,0.001121301,0.0003332343,0.0002903845,0.000942303,0.001508131,0.0008350095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005362909,"about_ca_system_score_gemma":0.0005953214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002495626,"about_ca_topic_score_gemma":0.0025577,"domain_scores_codex":[0.9988983,0.0001841161,0.0002389249,0.000147557,0.000362454,0.0001686815],"domain_scores_gemma":[0.9995271,0.00007233995,0.0001153603,0.00009945368,0.00006318166,0.0001226046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000360112,0.0005416071,0.0005567542,0.00006785476,0.000022001,0.000215767,0.00009199521,0.0005450318,0.9926285,0.001025551,0.000292055,0.003652813],"study_design_scores_gemma":[0.0001956785,0.0009688826,0.007506949,0.00005028633,0.00006384808,0.0007176271,0.000175169,0.006676952,0.9703951,0.0003185355,0.01286839,0.00006249002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9622344,0.001024633,0.0224346,0.0003738852,0.0002400357,0.001676307,0.006541698,0.0002951836,0.005179315],"genre_scores_gemma":[0.9119895,0.001435242,0.05798406,0.0002794298,0.00005550095,0.001364814,0.01644356,0.0002937893,0.01015399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002495626,"threshold_uncertainty_score":0.004962265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01274080281792251,"score_gpt":0.2500727653035436,"score_spread":0.2373319624856211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}