{"id":"W4364353336","doi":"10.1073/pnas.2212664120","title":"Mechanism of secretion of TcpF by the <i>Vibrio cholerae</i> toxin-coregulated pilus","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Simon Fraser University; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Pilus; Vibrio cholerae; Periplasmic space; Pilin; Secretion; Bacterial outer membrane; Microbiology; Cholera toxin; Biology; Cell biology; Escherichia coli; Bacteria; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002254722,0.0003504755,0.000221233,0.0002089905,0.0003280559,0.0008804066,0.000350551,0.0005778097,0.0003582429],"category_scores_gemma":[0.0001880651,0.0001555608,0.0004089953,0.00009330061,0.0004896597,0.0003635062,0.0003295069,0.0005112822,0.0003597699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001199347,"about_ca_system_score_gemma":0.0004857864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002067889,"about_ca_topic_score_gemma":0.0009075168,"domain_scores_codex":[0.999856,0.00001493211,0.000007574553,0.00002105821,0.00004539105,0.00005492045],"domain_scores_gemma":[0.9999158,0.00001035038,0.00002237975,0.00001098487,0.00001786663,0.00002255366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001513935,0.00004232435,0.001470752,0.0001061896,0.00001321242,0.0005152134,0.00008887964,0.0004213133,0.9918704,0.001744223,0.0003120205,0.00326413],"study_design_scores_gemma":[0.00008835315,0.0003436522,0.01915286,0.00004248256,0.00002604387,0.002018075,0.0003126762,0.007030571,0.9630295,0.0007035551,0.007214325,0.00003783222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858367,0.002794228,0.007442383,0.0004184582,0.0000782237,0.00006594424,0.0001847386,0.0001515524,0.003027739],"genre_scores_gemma":[0.995114,0.0009305831,0.001689911,0.00009632315,0.00001125961,0.0000278166,0.0002397912,0.00001879428,0.001871485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002067889,"threshold_uncertainty_score":0.008701921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899882074655471,"score_gpt":0.260122512186893,"score_spread":0.2411236914403383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}