{"id":"W4364354651","doi":"10.1111/mmi.15063","title":"Lysosomal swelling and lysis mediate delivery of C3 toxins to their cytoplasmic targets","year":2023,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children; St. Michael's Hospital; University of Guelph","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Biology; Cytoplasm; Lysis; Cell biology; Microbial toxins; Microbiology; Toxin; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001812231,0.0002749932,0.0002286296,0.0001428645,0.0002308192,0.000352914,0.0001756263,0.0004800091,0.0008691666],"category_scores_gemma":[0.0001873285,0.0001045365,0.0002807795,0.000134932,0.0003409082,0.0002796409,0.0003582949,0.000470664,0.0002976283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008845052,"about_ca_system_score_gemma":0.0004133261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001518718,"about_ca_topic_score_gemma":0.001085869,"domain_scores_codex":[0.9998103,0.00002805817,0.000008861337,0.00002391308,0.00005477442,0.00007410341],"domain_scores_gemma":[0.9998343,0.0000432394,0.00004172809,0.00002257909,0.00002784622,0.00003024213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008282589,0.000006644432,0.00009990376,0.00001828597,0.000002089043,0.00005813735,0.0000138541,0.00004228699,0.9991522,0.0001330073,0.00001777888,0.0003730357],"study_design_scores_gemma":[0.000007771998,0.00008855461,0.002470553,0.000003921745,0.00000306795,0.0002241912,0.00002755707,0.000853205,0.9957092,0.00005687013,0.0005521489,0.000002966789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930997,0.0009763383,0.004106069,0.00008271151,0.00001446666,0.00002929494,0.0002278406,0.00007252158,0.001391001],"genre_scores_gemma":[0.9978016,0.0001785774,0.0008550861,0.00003623961,0.000003623123,0.00001863363,0.0001211748,0.00001120252,0.0009737908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001518718,"threshold_uncertainty_score":0.006417572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006622453500088644,"score_gpt":0.2136073404967767,"score_spread":0.206984886996688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}