{"id":"W4364368816","doi":"10.1101/2023.04.10.536250","title":"Single-cell DNA replication dynamics in genomically unstable cancers","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Cycle for Survival; Memorial Sloan-Kettering Cancer Center","keywords":"Replication (statistics); DNA replication; Dynamics (music); DNA; Computer science; Computational biology; Biology; Cancer research; Genetics; Psychology; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001948228,0.000124079,0.0002340514,0.0005432995,0.000139755,0.0003979298,0.0001715356,0.0002296626,0.0003702659],"category_scores_gemma":[0.0006519762,0.0001766916,0.0001170368,0.0003690496,0.0001889046,0.0002885002,0.000200252,0.0003109163,0.000196574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000388735,"about_ca_system_score_gemma":0.0001044206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009658277,"about_ca_topic_score_gemma":0.001295046,"domain_scores_codex":[0.999903,0.00001114632,0.000005455071,0.00004265629,0.00002875529,0.000009001064],"domain_scores_gemma":[0.9997314,0.0001106924,0.00006448516,0.00003718604,0.00003353195,0.00002275454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001039306,0.00001434946,0.0123705,0.00003317871,0.00001653241,0.00004863262,0.0001059597,0.004070901,0.9753869,0.0002867007,0.00006510806,0.007497394],"study_design_scores_gemma":[0.000008140543,0.0001865731,0.1499218,0.000008148574,0.00003526802,0.0005737816,0.0001206973,0.0765325,0.7691192,0.001229385,0.002235495,0.00002900576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925028,0.0004403815,0.006376014,0.00001671284,0.000002583823,0.000004831325,0.0002631078,0.00008476736,0.0003086465],"genre_scores_gemma":[0.9930266,0.0003360237,0.005388683,0.00001303597,0.000003871398,0.00001472691,0.0006379063,0.00004039503,0.0005387231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009658277,"threshold_uncertainty_score":0.002820551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359330658134579,"score_gpt":0.2174879256208832,"score_spread":0.2038946190395374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}